Publication detail

The assessment of analgesic-residue contamination of wastewater using tandem gas chromatography with mass spectrometric detection

LACINA, P. MRAVCOVÁ, L. VÁVROVÁ, M.

Original Title

Type

abstract

Language

English

Original Abstract

This study is focused on determination of 10 selected drugs from the widely used group of human pharmaceuticals non-steroidal anti-inflammatory drugs (NSAID) in wastewater. Target compounds were follows: salicylic acid, acetylsalicylic acid, clofibric acid, ibuprofen, caffeine, naproxen, mefenamic acid, ketoprofen and diclofenac. Comprehensive twodimensional gas chromatography with mass spectrometric detection Time-of-Flight (GCxGCTOF MS) was used for final analysis of these compounds. Only disadvantage in this field is the necessity to derivatize selected compounds with suitable derivatization reagents. However, this work presents easy, effective and fast derivatization by silylation reagent MSTFA. Samples of wastewater were collected daily in November 2010 from the influent and effluent of WWTP in Brno Modrice in Czech Republic. Solid phase extraction (SPE) was used for extraction and preconcentration of analytes. The results of this study proves, that contamination of wastewater by human pharmaceuticals from the group on NSAID is relatively high. In addition, this study proves, that gas chromatography with mass spectrometric detection is excellent method for trace and ultratrace analysis of organic compounds, such as pharmaceuticals, due to its high separation efficiency and sensitivity. Limits of detection of this methods were ranged from 0.18 to 5 ng/L depending on specific compound. Concentrations of selected pharmaceuticals in wastewater varied from one to several tens of ug/L.

Keywords

analgesics, GCxGC-TOF MS, wastewater, drug residues

Authors

LACINA, P.; MRAVCOVÁ, L.; VÁVROVÁ, M.

Released

24. 9. 2011

Location

Ioannina

BibTex

@misc{BUT73742,
  author="Petr {Lacina} and Ludmila {Mravcová} and Milada {Vávrová}",
  title="The assessment of analgesic-residue contamination of wastewater using tandem gas chromatography with mass spectrometric detection",
  booktitle="16th International Symposium on Environmental Pollution and its Impact on Life in the Mediterranean Region: Book of Abstracts",
  year="2011",
  address="Ioannina",
  note="abstract"
}