Analysis of drug residuals in waste water by tandem gas chromatography with mass spectrometric detection

conference paper

English

This study is focused on the analysis of selected pharmaceuticals from the group of analgesics and sulfonamides in surface and waste water. These compounds are discharged to the sewer systems with human excrements after their administration either unchanged or as various metabolites and conjugates and enter the sewage treatment plants, where they are only partly removed during the cleaning process. Therefore they can be found in the discharged water or in sewage sludge and this way they enter the environment, where they can induce negative effects on organisms in soil and water ecosystems. Liquid chromatography with spectrophotometric or mass spectrometric detection is usually used for the analysis of these compounds. Nevertheless, gas chromatography offers substantially better separation efficiency based on fused silica capillary columns. Mass spectrometric detection with electron ionization enables reliable identification of separated compounds on the base of library searches. The only disadvantage of GC application in this field is usually the necessity of suitable derivatization of drugs in order to increase their volatility. Solid phase extraction was used for the isolation of target analytes from the waste water at influent and effluent of the municipal waste water treatment plant in Brno-Modřice. Orthogonal comprehensive two-dimensional gas chromatography with mass spectrometric detection (GCxGC-TOF MS) was used for their final analysis after derivatization with MSTFA.

Waste water, drug residuals, sulfonamides, analgesics, gas chromatography, mass spectrometry

ČÁSLAVSKÝ, J.; LACINA, P.; VÁVROVÁ, M.; MRAVCOVÁ, L.

2010

28. 5. 2010

Universita Pardubice

Pardubice

978-80-7395-282-2

Sborník 14. česko-slovenské spektroskopické konference

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