Hemostatic Wound Dressings for Accelerated Blood Stop

abstract

English

Each year, over 2 million people die from blood loss, making it a leading cause of mortality in trauma and surgical patients. Many of these deaths could be prevented with timely intervention and appropriate medical tools, such as hemostatic wound dressings. These dressings play a critical role in controlling bleeding in diverse settings, including homes, hospitals, and battlefield conditions, by enhancing the body’s natural clotting mechanisms. While traditional materials like collagen and gelatin have been widely used, recent advancements have shifted towards developing novel, non-animal-origin hemostatic agents with improved efficacy, biocompatibility, and biodegradability. This study investigates the preparation, characterization, and performance evaluation of novel hemostatic materials based on oxidized cellulose, chitosan, and carboxymethyl cellulose. These materials were fabricated in various forms — powders, nanofibers, films, and lyophilized foams — each tailored for specific wound types and to enhance bleeding control. Comprehensive testing included morphological analysis, physico-chemical property assessments, hemostatic efficacy studies, and cytotoxicity evaluations. The findings offer valuable insights into the potential of these materials as next-generation hemostatic agents for a wide range of clinical and emergency applications.

Wound dressings, hemostasis, blood clot

21. 10. 2024

Telč. Czech Republic

14

14

41