Publication detail

G-quadruplex propensity in H. neanderthalensis, H. sapiens and Denisovans mitochondrial genomes

BRÁZDA, V. ŠISLEROVÁ, L. MERGNY, J. CUCCHIARINI, A.

Original Title

G-quadruplex propensity in H. neanderthalensis, H. sapiens and Denisovans mitochondrial genomes

Type

journal article in Web of Science

Language

English

Original Abstract

Current methods of processing archaeological samples combined with advances in sequencing methods lead to disclosure of a large part of H. neanderthalensis and Denisovans genetic information. It is hardly surprising that the genome variability between modern humans, Denisovans and H. neanderthalensis is relatively limited. Genomic studies may provide insight on the metabolism of extinct human species or lineages. Detailed analysis of G-quadruplex sequences in H. neanderthalensis and Denisovans mitochondrial DNA showed us interesting features. Relatively similar patterns in mitochondrial DNA are found compared to modern humans, with one notable exception for H. neanderthalensis. An interesting difference between H. neanderthalensis and H. sapiens corresponds to a motif found in the D-loop region of mtDNA, which is responsible for mitochondrial DNA replication. This area is directly responsible for the number of mitochondria and consequently for the efficient energy metabolism of cell. H. neanderthalensis harbor a long uninterrupted run of guanines in this region, which may cause problems for replication, in contrast with H. sapiens, for which this run is generally shorter and interrupted. One may propose that the predominant H. sapiens motif provided a selective advantage for modern humans regarding mtDNA replication and function.

Keywords

mitochondria, genome evolution, G-quadruplex, replication, paleogenomics

Authors

BRÁZDA, V.; ŠISLEROVÁ, L.; MERGNY, J.; CUCCHIARINI, A.

Released

30. 5. 2024

Publisher

OXFORD UNIV PRESS

Location

OXFORD

ISBN

2631-9268

Periodical

NAR Genomics and Bioinformatics

Year of study

6

Number

2

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1

Pages to

10

Pages count

10

URL

https://academic.oup.com/nargab/article/6/2/lqae060/7685155?utm_source=etoc&utm_campaign=nargab&utm_medium=email

BibTex

@article{BUT189109,
  author="Václav {Brázda} and Lucie {Šislerová} and Jean-Louis {Mergny} and Anne {Cucchiarini}",
  title="G-quadruplex propensity in H. neanderthalensis, H. sapiens and Denisovans mitochondrial genomes",
  journal="NAR Genomics and Bioinformatics",
  year="2024",
  volume="6",
  number="2",
  pages="1--10",
  doi="10.1093/nargab/lqae060",
  issn="2631-9268",
  url="https://academic.oup.com/nargab/article/6/2/lqae060/7685155?utm_source=etoc&utm_campaign=nargab&utm_medium=email"
}