Publication detail
High-resolution LA-ICP-MS imaging of Pt-derivatives in single cell and tumour tissue
KOŽNAROVÁ, S. VAŠINOVÁ GALIOVÁ, M. NOVOTNÁ, M. HRSTKA, R.
Original Title
High-resolution LA-ICP-MS imaging of Pt-derivatives in single cell and tumour tissue
Type
conference proceedings
Language
English
Original Abstract
In this work, the single cells and soft tissues after cisplatin treatment were investigated by LA ICP MS system provided high resolved 2D multielemental images. Moreover, platinum distribution in single cells was monitored at various time intervals after drug uptake, simultaneously with Pt secretion by extracellular vesicles. Additionally, platinum transfer within tumour clinical specimens was investigated resulting in assessment that the platinum was excluded from the active tumour. Besides Pt, other elements such as Cu, Zn were monitored to assess elemental transfer and to indicate potential self resistance mechanisms in real clinical specimens. The obtained results enable further research of tumour tissue resistance and testing of tumour responses to different drug doses.
Keywords
LA-ICP-MS; PLATINUM DERIVATIVES; 2D IMAGING; CANCER
Authors
KOŽNAROVÁ, S.; VAŠINOVÁ GALIOVÁ, M.; NOVOTNÁ, M.; HRSTKA, R.
Released
2. 7. 2024
ISBN
978-94-6498-854-3
Book
Book of abstract of the 16th European Workshop on Laser Ablation (EWLA2024)
BibTex
@proceedings{BUT189068,
editor="KOŽNAROVÁ, S. and VAŠINOVÁ GALIOVÁ, M. and NOVOTNÁ, M. and HRSTKA, R.",
title="High-resolution LA-ICP-MS imaging of Pt-derivatives in single cell and tumour tissue",
year="2024",
isbn="978-94-6498-854-3"
}