Enhancing protein release from bone scaffolds via encapsulation into either liposomes or polymersomes

abstract

English

In the proposed research, the pro-healing, as well as antibacterial proteins, were incorporated into liposomes and two types of polymersomes, offering additional safeguarding for the protein throughout the bone scaffold curing process and ensuring more precise analysis of the protein‘s release kinetics from the scaffold onto the wound site. The term „polymersome“ for vesicles made from block copolymers was coined in 1999 (2). Polymersomes are similar to liposomes, vesicles formed from naturally occurring lipids. While having many of the properties of natural liposomes, polymersomes exhibit increased stability and reduced permeability. Furthermore, the use of synthetic polymers enables designers to manipulate the characteristics of the membrane and thus control permeability, release rates, stability and other properties of the polymersome. Both proteins were encapsulated in various types of particles, including lipidbased, biopolymer-based, and synthetic polymer-based particles. The encapsulation m

prohealing protein, bone scaffolds, protein release

KADLECOVÁ, Z.; LYSÁKOVÁ, K.; HLINÁKOVÁ, K.; MENČÍK, P.; VOJTOVÁ, L.

25. 5. 2024

České vysoké učení technické v Praze

Praha

978-80-01-07293-6

Bioimplantologie a regenerativní medicína 2024

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https://921c88450d.clvaw-cdnwnd.com/17e12706bb26b88046060a8921d16f31/200000499-73ed673ed8/bioimplantologie_2024_sbornik.pdf?ph=921c88450d