Study of physicochemical properties of skin creams with the addition of liposomes

article in a collection out of WoS and Scopus

English

This work aimed to design a formulation and prepare a native skin cream and skin creams enriched with liposomal particles with encapsulated vitamin E. The raw materials for creams were selected after thorough research. The liposomal particles were prepared by sonication method using an ultrasonic homogenizer. The prepared liposomes were stored at 4°C and the creams at a laboratory temperature of 25°C during the measurement period. After the preparation of the skin creams, their stability and rheological properties were studied at given time intervals during storage for 12 weeks. The stability of the prepared samples was determined using a LUMiSizer analytical centrifuge with STEP-Technology. Among the rheological properties, changes in the rate of structure recovery of the formulations were monitored, as well as changes in zero and infinite viscosity, which can be presented as changes in viscosity during product storage and changes in viscosity during application and spreading on the skin. All stability and rheological tests were performed for a temperature of 25 °C, which also corresponded to the storage temperature, and for a temperature of 37 °C, which approximately corresponds to the human body temperature. Stability tests showed that at laboratory temperature the sample of the native skin cream was the most stable, while the sample with the addition of 20 wt.% of liposomal particles was determined to be the least stable. At increased experimental temperatures, the stability of all samples decreased. The sample with 10 wt.% liposome addition showed the highest stability at increased temperature initially, however, the native lotion sample again proved to be the most stable during aging. In contrast, creams with a higher addition of liposomal particles were significantly unstable at increased temperatures. At the storage temperature, the sample with 10 wt.% and 30 wt.% liposome addition showed the smallest changes over time in the zero-viscosity measurement. In contrast, at increased temperature, the sample with 10 wt.% liposome addition and the native sample showed the highest changes in zero viscosity. When the infinite viscosity was analyzed at laboratory temperature, it was found that the viscosity changed the least over time for the lotion without adding liposomes. In contrast, the most significant changes were observed for the sample with 10 wt.% addition of liposomal particles. When analysed at increased temperature, it was found that the sample with 10 wt.% addition immediately after preparation should be the most spreadable in practice. In contrast, the sample with 30 wt.% liposomes at 12 weeks of age was found to be the least spreadable. When thixotropic properties were studied, it was found that the native lotion sample showed the highest recovery rate at both laboratory and increased temperature. For all samples, a general decrease in regenerative ability with aging time was observed. The size and stability of the prepared liposomal particles with encapsulated vitamin E were monitored by DLS and zeta-potential determination. The prepared particles showed the smallest particle size (197.2 ± 2.9 nm) and polydispersity (0.218 ± 0.014) at 4 weeks of age after preparation, while the largest particle size (260.1 ± 34.1 nm) and polydispersity (0.398 ± 0.059) were measured after 8 weeks of age. Using stability analysis, it was found that except for the particles at 8 weeks of age, all reached values below -30 mV, thus exceeding the stability limit of ±30 mV and can be considered stable.

cosmetic emulsion, long-term stability, liposomes, rheology

MÜLLEROVÁ, K.; ENEV, V.

30. 11. 2023

FCH VUT

Brno

978-80-214-6204-5

Chemie je život 2023 - Sborník příspěvků

VUT

první

27

37

11

https://www.fch.vut.cz/vav/konference/sok/vystupy/sbornik-fulltextu-2023-final-pdf-p252621