Publication detail

Interaction of Platinum Derivatives with Cancerous Cells

KOŽNAROVÁ, S. VAŠINOVÁ GALIOVÁ, M. HRSTKA, R.

Original Title

Type

conference proceedings

Language

English

Original Abstract

Exosomes have been found to have a role in the efflux of platinum derivatives from cells. The aim of this work was the confirmation of existing scientific hypotheses and the refinement of these hypotheses in the light of new information via SN-ICP-MS analysis. The influence of the concentration of the drug and the duration of the treatment on the uptake and efflux of platinum by the cells was the subject of the study. LA-ICP-MS was used for 2D imaging, especially for the visualization of the spatial distribution of platinum. The obtained results showed that platinum accumulates in the regions of the cell nuclei. LA-ICP-MS was also used for bulk analysis of single cells. The measurements confirmed the linearity of the trend in the dependence of the amount of platinum in the cells on the concentration of the chemotherapeutic agent during treatment.

Keywords

CISPLATIN; EXOSOMES; ICP-MS; 2D IMAGING; LA-ICP-MS; OVARIAN CANCER

Authors

KOŽNAROVÁ, S.; VAŠINOVÁ GALIOVÁ, M.; HRSTKA, R.

Released

30. 11. 2023

ISBN

978-80-214-6204-5

Book

Studentská odborná konference Chemie je život 2023 Sborník abstraktů

Edition number

první

BibTex

@proceedings{BUT186972,
  editor="KOŽNAROVÁ, S. and VAŠINOVÁ GALIOVÁ, M. and HRSTKA, R.",
  title="Interaction of Platinum Derivatives with Cancerous Cells",
  year="2023",
  number="první",
  isbn="978-80-214-6204-5"
}