Publication detail

BIOMECHANICAL AND STRUCTURAL EVALUATION OF THE EFFECT OF GLYCEROL ON A RESORABLE CHITOSAN/CELLULOSE SCAFFOLD FOR SKIN TISSUE ENGINEERING.

VERČIMÁKOVÁ, K. KARBOWNICZEK, J. STACHEWICZ, U. VOJTOVÁ, L.

Original Title

BIOMECHANICAL AND STRUCTURAL EVALUATION OF THE EFFECT OF GLYCEROL ON A RESORABLE CHITOSAN/CELLULOSE SCAFFOLD FOR SKIN TISSUE ENGINEERING.

Type

abstract

Language

English

Original Abstract

The main objective of the study is to enhance the biomechanical properties and stability of porous chitosan/cellulose scaffolds in a simple one-step fabrication process without any additional crosslinking agents. We investigated the stability of manufactured scaffolds in medium and biocompatibility to verify their degradation time and effect of the degradation product on cells. In the presented study, the effect of glycerol on the chitosan (Chit) scaffold mixed with either oxidized cellulose (Chit/OC), or carboxymethyl cellulose (Chit/CMC) was evaluated. Incorporation of glycerol into porous structures has shown a significant enhancement of viscoelastic properties. The elasticity of the material was 5-fold higher under dry conditions, while the strength of the material grew approximately 20-fold under hydrated conditions. The addition of glycerol significantly improved the enzymatic stability of the scaffolds and the stability in cell culture medium. Four times greater stability has been shown mainly for the Chit/CMC scaffold supplemented with glycerol, while it also reduced the amount of released degradation products, continuously measured over 21 days in enzymatic medium. Glycerol supplementation into porous scaffold could eliminate the utility of commonly used crosslinking agents. Furthermore, glycerol created a more hydrophobic character in the material and lowered swelling properties, while the porosity and pore sizes were not significantly influenced.

Keywords

wound healing, chitosan, cellulose, glycerol

Authors

VERČIMÁKOVÁ, K.; KARBOWNICZEK, J.; STACHEWICZ, U.; VOJTOVÁ, L.

Released

12. 10. 2023

Publisher

Polish Society for Biomaterials, Scientific Publishing House „Akapit”

Location

Krakow

Pages from

97

Pages to

97

Pages count

121

URL

http://biomat.krakow.pl/files/konferencje/rytro/rytro_2023_conference_proceedings.pdf

BibTex

@misc{BUT185713,
  author="Katarína {Verčimáková} and Joanna {Karbowniczek} and Urszula {Stachewicz} and Lucy {Vojtová}",
  title="BIOMECHANICAL AND STRUCTURAL EVALUATION OF THE EFFECT OF GLYCEROL ON A RESORABLE CHITOSAN/CELLULOSE SCAFFOLD FOR SKIN TISSUE ENGINEERING.",
  year="2023",
  pages="121",
  publisher="Polish Society for Biomaterials, Scientific Publishing House „Akapit”",
  address="Krakow",
  url="http://biomat.krakow.pl/files/konferencje/rytro/rytro_2023_conference_proceedings.pdf",
  note="abstract"
}