Publication detail

Smart Antibacterial Nanoparticle Delivery System for the Treatment of Infected Wounds

POLÁKOVÁ, V. FOHLEROVÁ, Z. VOJTOVÁ, L.

Original Title

Type

abstract

Language

English

Original Abstract

Today, infected and chronic wounds represent a significant challenge in the field of regenerative medicine, primarily due to their potential to lead to severe complications, such as sepsis, a life threatening condition. In numerous cases, traditional antibiotics have proven ineffective due to the resistance exhibited by multiple strains of bacteria. There has been a growing focus on the development of new materials enriched with antibacterial nanoparticles to target bacterial strains that have acquired antibiotic resistance. In recent years, numerous drug and nanoparticle delivery systems have been developed, featuring pH-triggered release designed for the acidic pH environment in cancer treatment. Surprisingly, there have been only a few studies that aimed to create pH-responsive delivery systems for release in the alkaline pH region of infectious wounds. The primary objective of our work was to synthesize and characterize antibacterial copper nanoparticles using straightforward and robust method, favorably with faster release in the alkaline pH region of infectious wounds. The secondary goal was to develop a delivery material suitable for on wound application. The synthesis of copper nanoparticles starts with chemical reduction, followed by stabilization with chitosan of both, low and medium molecular weight. We characterized prepared samples using transmission electron microscopy, dynamic light scattering, and UV-VIS spectroscopy. Copper nanoparticles coated with medium molecular weight chitosan had an average radius of 203.9 nm, while low molecular weight chitosan coated copper nanoparticles had an average radius of 170.4 nm. As a delivery material, we are developing pH-responsive reduced albumin-based hydrogel. In conclusion, these antibacterial particles can enrich various delivery materials besides albumin based hydrogel, for example scaffolds or wound dressings.

Keywords

Smart material, nanoparticle, delivery, antibacterial, infected burns, infected wounds, copper, hydrogel, albumin

Authors

POLÁKOVÁ, V.; FOHLEROVÁ, Z.; VOJTOVÁ, L.

Released

30. 11. 2023

Publisher

Vysoké učení technické v Brně, Fakulta chemická, Purkyňova 464/118, 612 00 Brno

Location

Brno

ISBN

978-80-214-6204-5

Book

Studentská odborná konference Chemie je život 2023 Sborník abstraktů

Edition number

první

Pages from

Pages to

Pages count

BibTex

@misc{BUT185699,
  author="Veronika {Poláková} and Zdenka {Fohlerová} and Lucy {Vojtová}",
  title="Smart Antibacterial Nanoparticle Delivery System for the Treatment of Infected Wounds",
  booktitle="Studentská odborná konference Chemie je život 2023 
Sborník abstraktů",
  year="2023",
  edition="první",
  pages="64--64",
  publisher="Vysoké učení technické v Brně, Fakulta chemická, Purkyňova 464/118, 612 00 Brno",
  address="Brno",
  isbn="978-80-214-6204-5",
  note="abstract"
}