Publication detail

A synergistic effect of fibrous carboxymethyl cellulose with equine collagen improved the hemostatic properties of freeze-dried wound dressings

SEDLÁŘ, M. VERČIMÁKOVÁ, K. FOHLEROVÁ, Z. IZSÁK, D. CHALUPOVÁ, M. SUCHÝ, P. DOHNALOVÁ, M. SOPUCH, T. VOJTOVÁ, L.

Original Title

A synergistic effect of fibrous carboxymethyl cellulose with equine collagen improved the hemostatic properties of freeze-dried wound dressings

Type

journal article in Web of Science

Language

English

Original Abstract

Bleeding is one of the most commonly occurring injuries; it can be painful and even life-threatening condition. The hemostats are substances that promote blood clotting and fasten hemostasis. In this paper, we evaluated the hemostatic effect of freeze-dried wound dressings based on equine collagen, porcine collagen, fibrous carboxymethyl cellulose (CMC) and their mixtures. The wound dressings were investigated for their morphological structure, chemical structure, absorption properties, in vitro hemostasis, cytotoxicity assay and lastly, for in vivo hemostasis. We have found out that adding fibrous CMC into collagen-based hemostatic wound dressings creates a strong synergistic effect, which significantly improves absorption capacity by almost doubling it, as well as supports clotting time. Based on the in vivo studies on partial nephrectomy in rats, the time needed for achieving hemostasis was significantly lower due to the synergy of collagen and CMC. Our materials were compared to the commonly used hemostatic sealing patch on the market (Tachosil) during the in vivo testing, and sample of a mixture of equine collagen and CMC showed better hemostatic efficacy.

Keywords

Fibrous CMC; Equine collagen; Porcine collagen; Freeze-drying; Hemostatic agent

Authors

SEDLÁŘ, M.; VERČIMÁKOVÁ, K.; FOHLEROVÁ, Z.; IZSÁK, D.; CHALUPOVÁ, M.; SUCHÝ, P.; DOHNALOVÁ, M.; SOPUCH, T.; VOJTOVÁ, L.

Released

23. 8. 2023

Publisher

Springer Nature

Location

DORDRECHT

ISBN

0969-0239

Periodical

CELLULOSE

Year of study

30

Number

1

State

Kingdom of the Netherlands

Pages from

1

Pages to

19

Pages count

19

URL

https://link.springer.com/article/10.1007/s10570-023-05499-9

Full text in the Digital Library

http://hdl.handle.net/11012/245029

BibTex

@article{BUT185221,
  author="Marian {Sedlář} and Katarína {Verčimáková} and Zdenka {Fohlerová} and Dávid {Izsák} and Marta {Chalupová} and Pavel {Suchý} and Marcela {Dohnalová} and Tomáš {Sopuch} and Lucy {Vojtová}",
  title="A synergistic effect of fibrous carboxymethyl cellulose with equine collagen improved the hemostatic properties of freeze-dried wound dressings",
  journal="CELLULOSE",
  year="2023",
  volume="30",
  number="1",
  pages="19",
  doi="10.1007/s10570-023-05499-9",
  issn="0969-0239",
  url="https://link.springer.com/article/10.1007/s10570-023-05499-9"
}