Preparation of Liposome-enriched system for Controlled Release of Calendula Officinalis Extract in DFU Treatment

abstract

English

Diabetes affects millions globally, leading to diabetic foot ulcers (DFUs) with impaired healing and bacterial biofilm formation. Due to the misuse of antibiotics , there is a need for non-antibiotic alternatives, such as Calendula Officinalis extract, supporting faster wound closure and greater size reduction compared to antibiotics , improving the DFU treatment. Encapsulation into liposomes preserves the antioxidative and antibacterial activity of the extract, creating a drug-delivery system with controlled degradation and antibacterial activity for the intended application. In our previous study, the Calendula extract was found to be unstable. To preserve its activity, increase bioavailability, and ensure controlled release, the extract was encapsulated into liposomes using the Mozafari method (n=5). The liposomes remained stable over 28 days, maintaining diameters and a consistent zeta potential. Encapsulation efficiency, antioxidant activity, and total phenolic content were measured, showing positive effects and confirming the suitability of the encapsulated extract for the intended application. The liposomal Calendula Officinalis extract will be further incorporated into a suitable hydrogel and the release will be evaluated.

Encapsulation, drug delivery, liposomes, calendula officinalis, herbal extract

KADLECOVÁ, Z.; RYCHETSKÝ, M.; VÍTOVÁ, E.; VOJTOVÁ, L.

31. 8. 2023

Belgrade: Materials Research Society of Serbia

978-86-919111-8-8

THE TWENTY-FOURTH ANNUAL CONFERENCE YUCOMAT 2023 Program and Book of Abstracts Herceg Novi, September 4-8, 2023

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https://mrs-serbia.org.rs/images/2023/Yucomat_2023_Program_BoA.pdf