Publication detail

Gas-Free Amino- and Alkoxycarbonylation of Aryl Iodides in a Bioinspired Deep Eutectic Solvent with Mo(CO)6 as a Safe CO Source

MESSA, F. PAPARELLA, A. VESELÝ, D. KRAJČOVIČ, J. PAPADIA, P. PERRONE, S. SALOMONE, A.

Original Title

Gas-Free Amino- and Alkoxycarbonylation of Aryl Iodides in a Bioinspired Deep Eutectic Solvent with Mo(CO)6 as a Safe CO Source

Type

journal article in Web of Science

Language

English

Original Abstract

The Pd-catalyzed amino- and alkoxycarbonylation of aryl iodides has been exploited, for the first time, in a bioinspired Deep Eutectic Solvent and under gas-free conditions, by using Mo(CO)(6) as the CO source. The method allows for the preparation of carboxylic amides and esters in high yields (up to 99 %), short reaction time (2 h) and under mild reaction conditions (80 degrees C), with a low catalyst loading (2.5 mol %). Noteworthy, in the case of N-hexylbenzamide, it has been demonstrated that both the catalyst and DES can be used for four consecutive runs, with a moderate decrease of catalytic efficiency. The methodology has been also applied to the preparation of an Active Pharmaceutical Ingredient used for the treatment of human scabies and lice.

Keywords

alkoxycarbonylation; aminocarbonylation; Pd-catalysis; deep eutectic solvent; molybdenum hexacarbonyl

Authors

MESSA, F.; PAPARELLA, A.; VESELÝ, D.; KRAJČOVIČ, J.; PAPADIA, P.; PERRONE, S.; SALOMONE, A.

Released

22. 5. 2023

Publisher

Wiley-VCH

Location

WEINHEIM

ISBN

1434-193X

Periodical

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Year of study

26

Number

24

State

Federal Republic of Germany

Pages from

1

Pages to

8

Pages count

8

URL

https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejoc.202300309

Full text in the Digital Library

http://hdl.handle.net/11012/244939

BibTex

@article{BUT184175,
  author="Francesco {Messa} and Andrea Nicola {Paparella} and Dominik {Veselý} and Jozef {Krajčovič} and Paride {Papadia} and Serena {Perrone} and Antonio {Salomone}",
  title="Gas-Free Amino- and Alkoxycarbonylation of Aryl Iodides in a Bioinspired Deep Eutectic Solvent with Mo(CO)6 as a Safe CO Source",
  journal="EUROPEAN JOURNAL OF ORGANIC CHEMISTRY",
  year="2023",
  volume="26",
  number="24",
  pages="1--8",
  doi="10.1002/ejoc.202300309",
  issn="1434-193X",
  url="https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejoc.202300309"
}