Publication detail

Liposomal Form of Erlotinib for Local Inhalation Administration and Efficiency of Its Transport to the Lungs

SZABOVÁ, J. MIŠÍK, O. FUČÍK, J. MRÁZOVÁ, K. MRAVCOVÁ, L. ELCNER, J. LÍZAL, F. KRZYZANEK, V. MRAVEC, F.

Original Title

Liposomal Form of Erlotinib for Local Inhalation Administration and Efficiency of Its Transport to the Lungs

Type

journal article in Web of Science

Language

English

Original Abstract

This contribution is focused on the preparation of a liposomal drug delivery system of erlotinib resisting the nebulization process that could be used for local treatment of non-small-cell lung cancer. Liposomes with different compositions were formulated to reveal their influence on the encapsulation efficiency of erlotinib. An encapsulation efficiency higher than 98 % was achieved for all vesicles containing phosphatidic acid (d ≈ 100 nm , ζ = – 43 mV) even in the presence of polyethylene glycol (d ≈ 150 nm, ζ = – 17 mV) which decreased this value in all other formulas. The three most promising formulations were nebulized by two air-jet and two vibrating mesh nebulizers, and the aerosol deposition in lungs was calculated by tools of computational fluid and particle mechanics. According to the numerical simulations and measurements of liposomal stability, air-jet nebulizers generated larger portion of the aerosol able to penetrate deeper into the lungs, but the delivery is likely to be more efficient when the formulation is administered by Aerogen Solo vibrating mesh nebulizer because of a higher portion of intact vesicles after the nebulization. The leakage of encapsulated drug from liposomes nebulized by this nebulizer was lower than 2 % for all chosen vesicles.

Keywords

Liposome, Non-small-cell lung cancer, Nebulization, Encapsulation, Aerodynamic particle size, Numerical simulations.

Authors

SZABOVÁ, J.; MIŠÍK, O.; FUČÍK, J.; MRÁZOVÁ, K.; MRAVCOVÁ, L.; ELCNER, J.; LÍZAL, F.; KRZYZANEK, V.; MRAVEC, F.

Released

7. 2. 2023

Publisher

Elsevier Science BV

Location

Holandsko

ISBN

0378-5173

Periodical

INTERNATIONAL JOURNAL OF PHARMACEUTICS

Year of study

634

Number

march

State

Kingdom of the Netherlands

Pages from

1

Pages to

12

Pages count

12

URL

https://www.sciencedirect.com/science/article/pii/S0378517323001151

BibTex

@article{BUT182463,
  author="Jana {Szabová} and Ondrej {Mišík} and Jan {Fučík} and Kateřina {Mrázová} and Ludmila {Mravcová} and Jakub {Elcner} and František {Lízal} and Vladislav {Krzyžánek} and Filip {Mravec}",
  title="Liposomal Form of Erlotinib for Local Inhalation Administration and Efficiency of Its Transport to the Lungs",
  journal="INTERNATIONAL JOURNAL OF PHARMACEUTICS",
  year="2023",
  volume="634",
  number="march",
  pages="1--12",
  doi="10.1016/j.ijpharm.2023.122695",
  issn="0378-5173",
  url="https://www.sciencedirect.com/science/article/pii/S0378517323001151"
}