Publication detail

Fluorescence study of some structural and compositional effects on the aggregation of hydrophobized hyaluronan

VELCER, T. MRAVEC, F. VENEROVÁ, T. CHANG, C. PEKAŘ, M.

Original Title

Fluorescence study of some structural and compositional effects on the aggregation of hydrophobized hyaluronan

Type

journal article in Web of Science

Language

English

Original Abstract

The aggregation behavior of four samples of hydrophobically modified hyaluronan was examined in water and in 0.15 M NaCl. The samples differed in the length of their hydrocarbon modifying chains, degree of substitution, or hyaluronan molecular weight. The critical aggregation concentration was determined by fluorescence spec-troscopy using pyrene as a probe. Aggregation was observed even with hyaluronan modified by a short alkyl chain (C6). The critical aggregation concentration decreased with increasing alkyl chain length and with increasing hyaluronan molecular weight at a comparable degree of substitution. Aggregation was detected over a rather broad concentration interval, indicating a progressive formation of aggregates. Two populations of ag-gregates were detected for the oleyl substitution. The addition of NaCl had only minor effect on the critical aggregation concentration.

Keywords

Hydrophobically modified hyaluronan; Degree of substitution; Critical aggregation concentration; Fluorescence; Pyrene

Authors

VELCER, T.; MRAVEC, F.; VENEROVÁ, T.; CHANG, C.; PEKAŘ, M.

Released

31. 10. 2022

Publisher

ELSEVIER

Location

AMSTERDAM

ISBN

2215-0382

Periodical

Colloids and Interface Science Communications

Year of study

51

Number

100667

State

Kingdom of the Netherlands

Pages from

1

Pages to

6

Pages count

6

URL

https://www.sciencedirect.com/science/article/pii/S2215038222000942?via%3Dihub

BibTex

@article{BUT181399,
  author="Tomáš {Velcer} and Filip {Mravec} and Tereza {Venerová} and Chien-Hsiang {Chang} and Miloslav {Pekař}",
  title="Fluorescence study of some structural and compositional effects on the aggregation of hydrophobized hyaluronan",
  journal="Colloids and Interface Science Communications",
  year="2022",
  volume="51",
  number="100667",
  pages="6",
  doi="10.1016/j.colcom.2022.100677",
  issn="2215-0382",
  url="https://www.sciencedirect.com/science/article/pii/S2215038222000942?via%3Dihub"
}