Application of bacterial cellulose in biomedicine

conference proceedings

English

Bacterial cellulose (BC) is one of the most interesting polysaccharides which is produced by microorganisms. Compared to plant cellulose, BC is synthesized without residues of other molecules such as lignin, hemicellulose, and pectin. The purity of the synthesized BC gives it an indisputable advantage over plant-based cellulose, which requires complex isolation and purifi cation. BC is structurally composed of a dense and organized 3D network of fi brils that form porous layers. This biopolymer is characterized by high crystallinity, thermal stability and bett er mechanical properties compared to plant cellulose. BC can absorb a large amount of water, is non-toxic, biocompatible, and hypoallergenic. Thanks to its high porosity, BC is able to carry molecules such as functional substances (antimicrobial, antioxidant, anti-infl ammatory, etc.) or benefi cial microorganisms (like probiotics or postbiotics) and then deliver them to a specifi c target, e.g. food packaging or wound healing. BC has enormous potential in a wide range of application. Currently, much att ention is focused on using BC in the biomedical fi eld. The versatility of this material demonstrates a wide range of individual possible applications, such as dressing materials and wound coverings, vascular grafts, scaff olds for tissue engineering or artifi cial blood vessels. Non-modifi ed BC has unique physical and mechanical properties. However, to make full use of the potential of BC, it is necessary to modify BC by various methods. By modifi cation, the chemical structure, porosity, crystallinity, or fiber density are changed. With adequately designed modifi cation, it is possible to significantly improve and adjust the resulting properties for a specifi c application. This work deals with a comparison between non-modifi ed BC membranes and modifi ed BC membranes by a crosslinker. The research was focused on the point of morphology, water content, swelling profi le, viscoelastic behaviour and adsorption capacity of BC. It was proved that BC could adsorb methyl orange or other anionic/cationic dyes. Composites intended for the targeted distribution of drugs can be prepared by adding antibiotics or other substances to the BC structures. However, the adsorption capacity of BC depends on the porosity and functional groups present on its surface. With a correctly chosen modifi cation we can prepare a composite that will meet the specifi ed requirements of particular applications.

Bacterial cellulose; modification; adsorption; mechanical properties

SOBKOVÁ, M.; STŘÍŽ, R.; KOVALČÍK, A.

30. 11. 2022

Vysoké učení technické v Brně, Fakulta chemická, Brno

Brno

978-80-214-6117-8

Studentská odborná konference, Chemie je život 2022, Sborník abstraktů

první

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