Publication detail

FUNCTIONALIZED LIPID NANOPARTICLES WITH ENCAPSULATED ANTIMICROBIAL ACTIVE COMPOUNDS

DZURICKÁ, L. MÁROVÁ, I.

Original Title

FUNCTIONALIZED LIPID NANOPARTICLES WITH ENCAPSULATED ANTIMICROBIAL ACTIVE COMPOUNDS

Type

abstract

Language

English

Original Abstract

Introduction: Lipid nanoparticles have been developed with the progress in nanotechnology and their unique properties have made them one of the most widely used nanoparticles [1]. Materials & Methods: The presented work is focused on two types of nanostructured particles, liposomes and PHB-liposome particles. Materials were functionalized by active compounds, thymol and vitamin E. Liposomes were overall tested for stability, gradual release of incorporated substances in the model environment and biological activity. Liposomal size and colloid stability were defined by dynamic light scattering and zeta-potential. Particles were subjected to the characterization of gradual release using the spectrophotometric method into model environments. Antimicrobial activity and synergic effect against gram-positive and gram-negative strains of microorganisms were also evaluated. To assess whether prepared nanostructured materials are suitable for further cosmetic applications, a cytotoxicity assay on HaCaT cell line was carried out. Results: It was observed that the used lipid particles were stable and showed antimicrobial and non-cytotoxic activity. Conclusion: To conclude, functional liposomal particles show promising results for various applications as cosmetic preservation and pharmaceutical antimicrobial products.

Keywords

lipid nanoparticles, liposomes, encapsulation, thymol, vitamin E, antimicrobial activity, cytotoxic activity

Authors

DZURICKÁ, L.; MÁROVÁ, I.

Released

28. 9. 2022

Publisher

15th World Congress on polyphenols applications 2022

Location

Valencia, Spain

Pages from

92

Pages to

92

URL

https://polyphenols-site.com/replay-abstracts-books

BibTex

@misc{BUT180668,
  author="Lucia {Dzurická} and Ivana {Márová}",
  title="FUNCTIONALIZED LIPID NANOPARTICLES WITH ENCAPSULATED ANTIMICROBIAL ACTIVE COMPOUNDS",
  year="2022",
  pages="92--92",
  publisher="15th World Congress on polyphenols applications 2022",
  address="Valencia, Spain",
  url="https://polyphenols-site.com/replay-abstracts-books",
  note="abstract"
}