Aminoclay as Drug Carrier

abstract

English

This study aimed to prepare new drug delivery system with use of aminoclay complexes to enhance the drug release and improve bioavailability of selected drugs. Aminoclay is a relatively new material that belongs to organically modified clays. It is a magnesium phylosilicate that contains 3-aminopropyl groups. The clay material thus modified is characterised by relatively good chemical and mechanical stability, showing no signs of toxicity even at higher concentration. Thanks to easy preparation, and thermal and mechanical stability of inorganic matrix and external amino groups is aminoclay a material with great potential for many applications. By binding the drug to the aminoclay matrix it is expected to improve properties such as solubility, stability, release, bioavailability, biodegradation, etc. For model samples was used a selection of the bioactive substances: curcumin, diclofenac, ibuprofen, merocyanin and tocopherol. For verification of binding drugs were used methods of FTIR (Fourier Transformation Infrared Spectroscopy) and EA (Elemental Analysis). Furthermore, the content of the bound bioactive substances to the aminoclay matrix was investigated using UPLC (Ultra Performance Liquid Chromatography). What is essential for therapeutic use of bioactive substances is their value of cytotoxicity. For this study MTT test for evaluation of cytotoxicity was used. The main motivation of this study was to create new complexes with improved characteristics that would replace existing forms of substances used in pharmaceutical and biomedical applications.

aminoclay, carrier, drug

DUŠEK, J.

26. 11. 2020

Vysoké učení technické v Brně, Fakulta chemická

Brno

987-80-214-5920-0

Studentská odborná konference CHEMIE JE ŽIVOT 2020

první

57

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