Publication detail
Plasticized poly(3‑hydroxybutyrate)/poly(d,l‑lactide) blends filled with tricalcium phosphate for FDM 3D printing and their biological properties
MELČOVÁ, V. CHALOUPKOVÁ, K. VOJTOVÁ, L. RAMPICHOVÁ, M.
Original Title
Plasticized poly(3‑hydroxybutyrate)/poly(d,l‑lactide) blends filled with tricalcium phosphate for FDM 3D printing and their biological properties
Type
abstract
Language
English
Original Abstract
Additive manufacturing or 3D printing is a production technology capable of producing nearly any desired shape including complex porous structures. Thanks to this, it is often exploited for the man-ufacturing of scaffolds for tissue engineering, a modern approach of regenerative medicine. In this work, we have successfully prepared plasticized poly(3-hydroxybutyrate)/polylactide 70/30 blends modified with bioceramic tricalcium phosphate (13 wt%) and used them for Fused Deposition Modeling 3D printing. Two commercial plasticizers, Citroflex B6 (n-Butyryl tri-n-hexyl citrate) and Syncroflex 3114 (oligomeric adipate ester), in the amount of 12 wt% were used. the materials were firstly subjected to print-ing parameters optimization, afterwards printability, thermal and mechanical testing and as well as series of biological tests in vitrowere conducted. Citroflex plasticizer was proven to be effective in enhancing the processability and mechanical properties of stud-ied biopolymer blend, however the biocompatibility of samples with this citrate-based plasticizer was rather poor. on the other hand, Syncroflex materials showed better warping properties than commercial grade PLA filament and moreover the results of bio-logical tests revealed its potential to be used for stem cell-seeded scaffolds for regenerative medicine of bones
Keywords
additive manufacturing; fused deposition modeling; poly(3-hydroxybutyrate); polylactide; tricalcium phosphate; regenerative medicine; tissue engineering; bone scaffolds
Authors
MELČOVÁ, V.; CHALOUPKOVÁ, K.; VOJTOVÁ, L.; RAMPICHOVÁ, M.
Released
27. 11. 2020
Publisher
Vysoké učení technické v Brně, Fakulta chemická
Location
Brno
ISBN
978-80-214-5920-0
Book
Sborník abstraktů Chemie je živo 2020
Edition number
1.
Pages from
106
Pages to
107
Pages count
166
URL
BibTex
@misc{BUT169253,
author="MELČOVÁ, V. and CHALOUPKOVÁ, K. and VOJTOVÁ, L. and RAMPICHOVÁ, M.",
title="Plasticized poly(3‑hydroxybutyrate)/poly(d,l‑lactide) blends filled with tricalcium phosphate for FDM 3D printing and their biological properties",
booktitle="Sborník abstraktů Chemie je živo 2020",
year="2020",
edition="1.",
pages="106--107",
publisher="Vysoké učení technické v Brně, Fakulta chemická",
address="Brno",
isbn="978-80-214-5920-0",
url="https://www.fch.vut.cz/vav/konference/sok/vystupy/sbornik-abstrakty-konference-2020-pdf-p198641",
note="abstract"
}Documents