Publication detail

Dried blood spot self‐sampling with automated capillary electrophoresis processing for clinical analysis

RYŠAVÁ, L. DVOŘÁK, M. KUBÁŇ, P.

Original Title

Type

journal article - other

Language

English

Original Abstract

A simple and convenient concept of blood sampling followed by a fully automated analysis is presented. A disposable sampling kit is used for accurate self‐sampling of capillary blood from a finger prick. A high throughput blood sampling is thus enabled, which is essential in many clinical assays and considerably improves life quality and comfort of involved subjects. The collected blood samples are mailed to a laboratory for a fully automated dried blood spot (DBS) processing and analysis, which are performed with a commercial capillary electrophoresis instrument. Quantitative results are obtained within 20 min from the DBS delivery to the laboratory. The presented concept is exemplified by the determination of warfarin blood concentrations and demonstrates excellent analytical performance. Moreover, this concept is generally applicable to a wide range of endogenous and exogenous blood compounds and represents a novel and attractive analytical tool for personalized human health monitoring.

Keywords

analytical methods, blood self-sampling, dried blood spots, electrophoresis, warfarin

Authors

RYŠAVÁ, L.; DVOŘÁK, M.; KUBÁŇ, P.

Released

9. 12. 2020

ISBN

1521-3757

Periodical

Angewandte Chemie

Year of study

132

Number

State

Federal Republic of Germany

Pages from

7171

Pages to

7178

Pages count

URL

https://doi.org/10.1002/anie.202012997

BibTex

@article{BUT166401,
  author="Lenka {Ryšavá} and Miloš {Dvořák} and Pavel {Kubáň}",
  title="Dried blood spot self‐sampling with automated capillary electrophoresis processing for clinical analysis",
  journal="Angewandte Chemie",
  year="2020",
  volume="132",
  number="51",
  pages="7171--7178",
  doi="10.1002/ange.202012997",
  issn="1521-3757",
  url="https://doi.org/10.1002/anie.202012997"
}