Publication detail

THE USE OF BIOACTIVE COMPOUNDS AND THEIR ENCAPSULATION INTO LIPOSOMES TO INCREASE THE EFFECTIVENESS AND CONTROL RELEASE

HOOVÁ, J. VYSOKÁ, M. DZURICKÁ, L. MATOUŠKOVÁ, P. MÁROVÁ, I.

Original Title

Type

conference paper

Language

English

Original Abstract

Extracts from naturally occurred sources, such as plants or microorganisms, have been recently tested for their interesting properties that can be used in food or cosmetic industry. The aim of this work is to encapsulate microbial compounds, some plant extracts and also model hydrophilic and hydrophobic substances. Chosen components were encapsulated into liposomes. Particle size and distributions of liposomes were analyzed by dynamic light scattering and their stability by using zeta potential. Spectrophotometric methods were used to measure encapsulation efficiency and to characterize the chosen plant extracts by its amount of total polyphenols, flavonoids and antioxidant activity. Chosen samples were analyzed for their antimicrobial activity and cytotoxicity. Serratia marcescens, Escherichia coli as gram-negative bacterias, Micrococcus luteus as gram-positive bacteria and fungal strain (Candida glabrata) were used to test antimicrobial activity. Human keratinocytes and mouse melanoma cells were used to cytotoxicity determination. It has been proved that encapsulation techniques help slowly release the active compounds from plant extracts and transport them to targeted location. Antimicrobial effect was also seen before and after encapsulation into liposomes. Moreover, none of the extracts showed evidence of cytotoxicity.

Keywords

Encapsulation; liposomes; polyphenols; antioxidant activity; antimicrobial activity; cytotoxicity

Authors

HOOVÁ, J.; VYSOKÁ, M.; DZURICKÁ, L.; MATOUŠKOVÁ, P.; MÁROVÁ, I.

Released

1. 1. 2019

Publisher

TANGER

Location

Ostrava, Czech republic

ISBN

978-80-87294-89-5

Book

NANOCON 2018, 10TH ANNIVERSARY INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION

Pages from

386

Pages to

391

Pages count

BibTex

@inproceedings{BUT163450,
  author="Julie {Hoová} and Marie {Vysoká} and Lucia {Dzurická} and Petra {Skoumalová} and Ivana {Márová}",
  title="THE USE OF BIOACTIVE COMPOUNDS AND THEIR ENCAPSULATION INTO LIPOSOMES TO INCREASE THE EFFECTIVENESS AND CONTROL RELEASE",
  booktitle="NANOCON 2018, 10TH ANNIVERSARY INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION
",
  year="2019",
  pages="386--391",
  publisher="TANGER",
  address="Ostrava, Czech republic",
  isbn="978-80-87294-89-5"
}