Publication detail

Advanced Material Catheter (AMCath), a minimally invasive endocardial catheter for the delivery of fast-gelling covalently cross-linked hyaluronic acid hydrogels

Dolan, Eimear B. Kovarova, Lenka O'Neill, Hugh Pravda, Martin Sulakova, Romana Scigalkova, Ivana Velebny, Vladimir Daro, Dorothee Braun, Nathalie Cooney, Gerard M. Bellavia, Gabriella Straino, Stefania Cavanagh, Brenton L. Flanagan, Aiden Kelly, Helena M. Duffy, Garry P. Murphy, Bruce P.

Original Title

Type

journal article in Web of Science

Language

English

Original Abstract

Injectable hydrogels that aim to mechanically stabilise the weakened left ventricle wall to restore cardiac function or to deliver stem cells in cardiac regenerative therapy have shown promising data. However, the clinical translation of hydrogel-based therapies has been limited due to difficulties injecting them through catheters. We have engineered a novel catheter, Advanced Materials Catheter (AMCath), that overcomes translational hurdles associated with delivering fast-gelling covalently cross-linked hyaluronic acid hydrogels to the myocardium. We developed an experimental technique to measure the force required to inject such hydrogels and determined the mechanical/viscoelastic properties of the resulting hydrogels. The preliminary in vivo feasibility of delivering fast-gelling hydrogels through AMCath was demonstrated by accessing the porcine left ventricle and showing that the hydrogel was retained in the myocardium post-injection (three 200 mu L injections delivered, 192, 204 and 183 mu L measured). However, the mechanical properties of the hydrogels were reduced by passage through AMCath (<= 20.62% reduction). We have also shown AMCath can be used to deliver cardiopoietic adipose-derived stem cell-loaded hydrogels without compromising the viability (80% viability) of the cells in vitro. Therefore, we show that hydrogel/catheter compatibility issues can be overcome as we have demonstrated the minimally invasive delivery of a fast-gelling covalently cross-linked hydrogel to the beating myocardium.

Keywords

Hydrogel; hyaluronic acid; catheter; myocardial infarction; minimally invasive delivery

Authors

Dolan, Eimear B.; Kovarova, Lenka; O'Neill, Hugh; Pravda, Martin; Sulakova, Romana; Scigalkova, Ivana; Velebny, Vladimir; Daro, Dorothee; Braun, Nathalie; Cooney, Gerard M.; Bellavia, Gabriella; Straino, Stefania; Cavanagh, Brenton L.; Flanagan, Aiden; Kelly, Helena M.; Duffy, Garry P.; Murphy, Bruce P.

Released

25. 10. 2018

Publisher

SAGE PUBLICATIONS LTD

Location

LONDON

ISBN

0885-3282

Periodical

JOURNAL OF BIOMATERIALS APPLICATIONS

Year of study

Number

State

United Kingdom of Great Britain and Northern Ireland

Pages from

681

Pages to

692

Pages count

URL

https://www.ncbi.nlm.nih.gov/pubmed/30354912

BibTex

@article{BUT163339,
  author="Dolan, Eimear B. and Kovarova, Lenka and O'Neill, Hugh and Pravda, Martin and Sulakova, Romana and Scigalkova, Ivana and Velebny, Vladimir and Daro, Dorothee and Braun, Nathalie and Cooney, Gerard M. and Bellavia, Gabriella and Straino, Stefania and Cavanagh, Brenton L. and Flanagan, Aiden and Kelly, Helena M. and Duffy, Garry P. and Murphy, Bruce P.",
  title="Advanced Material Catheter (AMCath), a minimally invasive endocardial catheter for the delivery of fast-gelling covalently cross-linked hyaluronic acid hydrogels",
  journal="JOURNAL OF BIOMATERIALS APPLICATIONS",
  year="2018",
  volume="33",
  number="5",
  pages="681--692",
  doi="10.1177/0885328218805878",
  issn="0885-3282",
  url="https://www.ncbi.nlm.nih.gov/pubmed/30354912"
}