Publication detail

The development of a silicone vaginal ring with a prostaglandin analogue for potential use in the treatment of canine reproductive disorders

NOVÁKOVÁ TKADLEČKOVÁ, V. VYSLOUŽIL, J. KUBOVÁ, K. ELBL, J. BUČKOVÁ, D. MUSELÍK, J. VETCHÝ, D. NOVOTNÝ, R. PROKS, P. JANČÁŘ, J. POLÁČEK, P.

Original Title

The development of a silicone vaginal ring with a prostaglandin analogue for potential use in the treatment of canine reproductive disorders

Type

journal article in Web of Science

Language

English

Original Abstract

In veterinary medicine, vaginal rings (VRs) are rarely used. However, there are diseases of female dogs' reproductive system which represent a suitable possibility for their usage. An example of such a disease is canine pyometra which can be treated by lipophilic prostaglandin drugs, unfortunately with harmful side effects after systemic administration. The aim of the study was to prove that the matrix VR based on silicone and channel-forming substance can be successfully used as a carrier for a three-day delivery of prostaglandin E-2 (PGE(2)). Based on an in-vitro release study, an optimum channel-forming substance and its concentration were selected. The results were implemented during the construction of VR from the medical grade silicone DDU-4840 with PGE(2) (5 mg). Glucose anhydrous in the 30% concentration was chosen as the most functional channel-forming substance due to synergism of osmotic activity and solubility. The DDU-VR containing PGE(2) and 30% of glucose anhydrous exhibited excellent mechanical characteristics and ensured 29% drug release through water-filled channels in first-order kinetic manner. This is eight times higher than a sample without glucose where molecular diffusion through the silicone matrix was dominating the release mechanism. Moreover, drug-free VRs were tested for mechanical resistance and the design of removal thread.

Keywords

Drug delivery; vaginal ring; silicone; channel-forming substance; prostaglandin; canine pyometra

Authors

NOVÁKOVÁ TKADLEČKOVÁ, V.; VYSLOUŽIL, J.; KUBOVÁ, K.; ELBL, J.; BUČKOVÁ, D.; MUSELÍK, J.; VETCHÝ, D.; NOVOTNÝ, R.; PROKS, P.; JANČÁŘ, J.; POLÁČEK, P.

Released

21. 6. 2019

Publisher

TAYLOR & FRANCIS LTD

Location

ABINGDON

ISBN

1097-9867

Periodical

Pharmaceutical Development and Technology

Year of study

24

Number

8

State

United States of America

Pages from

1021

Pages to

1031

Pages count

11

URL

https://www.tandfonline.com/doi/full/10.1080/10837450.2019.1622565

BibTex

@article{BUT162431,
  author="Veronika {Nováková Tkadlečková} and Jakub {Vysloužil} and Kateřina {Kubová} and Jan {Elbl} and Darja {Bučková} and Jan {Muselík} and David {Vetchý} and Robert {Novotný} and Pavel {Proks} and Josef {Jančář} and Petr {Poláček}",
  title="The development of a silicone vaginal ring with a prostaglandin analogue for potential use in the treatment of canine reproductive disorders",
  journal="Pharmaceutical Development and Technology",
  year="2019",
  volume="24",
  number="8",
  pages="1021--1031",
  doi="10.1080/10837450.2019.1622565",
  issn="1097-9867",
  url="https://www.tandfonline.com/doi/full/10.1080/10837450.2019.1622565"
}