Publication detail

Transport of a model diffusion probe in polyelectrolyte-surfactant hydrogels

KLUČÁKOVÁ, M. JARÁBKOVÁ, S. VELCER, T. KALINA, M. PEKAŘ, M.

Original Title

Transport of a model diffusion probe in polyelectrolyte-surfactant hydrogels

Type

journal article in Web of Science

Language

English

Original Abstract

Interactions of biopolymeric electrolytes with oppositely charged surfactants can result in micelle-like nanocontainers capable to dissolve hydrophobic substances. These micelle-like nanostructures can solve problems with hydrophobic nature of pharmaceutically active substances and be potentially usable for medical applications. In this study, two types of hydrogels were prepared: 1) based on hyaluronan and cationic surfactant septonex (carbethoxypendecinium bromide) and 2) based on diethylaminoethyl dextran and sodium dodecylsulphate. Nile red as a dye diffusion probe was incorporated into hydrogel in their preparation and then its release into surfactant solution and physiological saline was monitored. The release of NR from hydrogels was characterized by the effective diffusion coefficients of NR and structural parameters of hydrogels. The diffusion of NR in hydrogels was dependent on the molecular weight of polyelectrolyte and the ratio between charges of polyelectrolyte and surfactant. In the case of lower ratios, a bigger part of NR was probably incorporated in “pearl necklace structure” which suppressed its mobility. The increase of concentration of surfactant was connected with higher content of NR in free micelles or micelle-like aggregates and the increase in the release of NR. The formation of bigger micelles based on NR and SDS (in comparison with micelles based on NR and septonex surfactant) resulted in their lower diffusivity.

Keywords

Hyaluronan; Cationized dextran; Surfactant; Dye; Diffusion

Authors

KLUČÁKOVÁ, M.; JARÁBKOVÁ, S.; VELCER, T.; KALINA, M.; PEKAŘ, M.

Released

17. 4. 2019

Publisher

Elsevier

ISBN

0927-7757

Periodical

Colloids and Surfaces A: Physicochemical and Engineering Aspects

Year of study

573

Number

1

State

Kingdom of the Netherlands

Pages from

73

Pages to

79

Pages count

7

URL

https://www.sciencedirect.com/science/article/pii/S0927775719301700

BibTex

@article{BUT156663,
  author="Martina {Klučáková} and Sabína {Jarábková} and Tomáš {Velcer} and Michal {Kalina} and Miloslav {Pekař}",
  title="Transport of a model diffusion probe in polyelectrolyte-surfactant hydrogels",
  journal="Colloids and Surfaces A: Physicochemical and Engineering Aspects",
  year="2019",
  volume="573",
  number="1",
  pages="73--79",
  doi="10.1016/j.colsurfa.2019.04.042",
  issn="0927-7757",
  url="https://www.sciencedirect.com/science/article/pii/S0927775719301700"
}