Publication detail

STUDY OF FLOW PROPERTIES OF POWDERS IN PHARMACEUTICAL INDUSTRY

KOLESA, P. KLUČÁKOVÁ, M. GAVENDA, A.

Original Title

STUDY OF FLOW PROPERTIES OF POWDERS IN PHARMACEUTICAL INDUSTRY

Type

article in a collection out of WoS and Scopus

Language

English

Original Abstract

The main purpose of presented work is study of two model batches of APIs which were characterized by different flow properties (especially different tendency to caking). Immunosuppressant drug Mycophenolic Acid (MPA) was chosen such as model substance for this study, because this API caused large troubles in production due to presence of large lumps which clogged the hopper and it was very difficult to transport the sample through the pipeline. This issue had an adverse impact on production efficiency and it was necessary to find the relevant properties and parameters which affect lumps creation. Therefore many physico-chemical techniques were used for characterization of chosen batches of MPA.

Keywords

API; flowability; caking; polymorphism; handling

Authors

KOLESA, P.; KLUČÁKOVÁ, M.; GAVENDA, A.

Released

11. 12. 2018

Publisher

Czech Chemical Society

Location

Prague

ISBN

2336-7210

Book

Czech Chemical Society Symposium Series

ISBN

2336-7210

Periodical

Czech Chemical Society Symposium Series

Year of study

16

Number

6

State

Czech Republic

Pages from

498

Pages to

503

Pages count

528

URL

http://www.ccsss.cz/index.php/ccsss/issue/view/18/showToc

BibTex

@inproceedings{BUT156062,
  author="Pavel {Kolesa} and Martina {Klučáková} and Aleš {Gavenda}",
  title="STUDY OF FLOW PROPERTIES OF POWDERS IN PHARMACEUTICAL INDUSTRY",
  booktitle="Czech Chemical Society Symposium Series",
  year="2018",
  journal="Czech Chemical Society Symposium Series",
  volume="16",
  number="6",
  pages="498--503",
  publisher="Czech Chemical Society",
  address="Prague",
  isbn="2336-7210",
  issn="2336-7210",
  url="http://www.ccsss.cz/index.php/ccsss/issue/view/18/showToc"
}