Publication detail

Quantitative determination of the veterinary drug monensin in horse feed samples by square wave voltammetry (SWV) and direct infusion electrospray ionization tandem mass spectrometry (DI–ESI–MS/MS)

RUDNICKI, K. LANDOVÁ, P. WROŃSKA, M. DOMAGALA, S. ČÁSLAVSKÝ, J. VÁVROVÁ, M. SKRZYPEK, S.

Original Title

Quantitative determination of the veterinary drug monensin in horse feed samples by square wave voltammetry (SWV) and direct infusion electrospray ionization tandem mass spectrometry (DI–ESI–MS/MS)

Type

journal article in Web of Science

Language

English

Original Abstract

This paper presents for the first time the determination of monensin monosodium salt (MnzNa) by means of square wave voltammetry (SWV), cyclic voltammetry (CV), and, in parallel, direct infusion electrospray ionization tandem mass spectrometry (DI–ESI–MS/MS). The influence of various factors, such as pH, buffer composition, and SWV parameters on current response was studied. The best SWV signal was obtained at about −1.50 V versus an Ag/AgCl/KCl reference electrode in Britton–Robinson (B–R) buffer. Under optimal conditions, the SWV response of the renewable silver amalgam film electrode Hg(Ag)FE was linear over two MnzNa concentration ranges, from 7.5×10−8 to 5.0×10−7 mol L−1 and from 5.0×10−7 to 1.0×10−5 mol L−1. The limits of detection and quantification were 1.27×10−8 mol L−1 and 4.23×10−8 mol L−1, respectively. The applicability of the developed SWV method was investigated in the determination of MnzNa in horse feed by the standard addition method. CV was applied to understand the electrode mechanism of MnzNa. Finally, direct infusion electrospray ionization tandem mass spectrometry (DI–ESI–MS/MS) was used to determine MnzNa in horse feed samples by the external calibration method. The detector response was linear in the concentration range of 1.1×10−7 to 1.4×10−6 mol L−1. The obtained limits of detection and quantification were 3.4×10−8 mol L−1 and 1.1×10−7 mol L−1, respectively. Statistical analysis of MnzNa determination results from SWV and DI–ESI–MS/MS did not reveal any significant differences between them.

Keywords

Monensin, renewable silver amalgam film electrode, square wave voltammetry, direct infusion electrospray ionization tandem mass spektrometry, horse feed

Authors

RUDNICKI, K.; LANDOVÁ, P.; WROŃSKA, M.; DOMAGALA, S.; ČÁSLAVSKÝ, J.; VÁVROVÁ, M.; SKRZYPEK, S.

Released

18. 5. 2018

Publisher

Elsevier

Location

Amsterdam, Holandsko

ISBN

0026-265X

Periodical

MICROCHEMICAL JOURNAL

Year of study

141

Number

1

State

Kingdom of the Netherlands

Pages from

220

Pages to

228

Pages count

9

URL

https://doi.org/10.1016/j.microc.2018.05.032

BibTex

@article{BUT148460,
  author="RUDNICKI, K. and LANDOVÁ, P. and WROŃSKA, M. and DOMAGALA, S. and ČÁSLAVSKÝ, J. and VÁVROVÁ, M. and SKRZYPEK, S.",
  title="Quantitative determination of the veterinary drug monensin in horse feed samples by square wave voltammetry (SWV) and direct infusion electrospray ionization tandem mass spectrometry (DI–ESI–MS/MS)",
  journal="MICROCHEMICAL JOURNAL",
  year="2018",
  volume="141",
  number="1",
  pages="220--228",
  issn="0026-265X",
  url="https://doi.org/10.1016/j.microc.2018.05.032"
}