Publication detail

Evaluation and improvement of organic semiconductors’ biocompatibility towards fibroblasts and cardiomyocytes

ŠAFAŘÍKOVÁ, E. ŠINDLEROVÁ, L. STŘÍTESKÝ, S. KUBALA, L. VALA, M. WEITER, M. VÍTEČEK, J.

Original Title

Type

journal article in Web of Science

Language

English

Original Abstract

The use of organic semiconductors in bioelectronic devices has received considerable attention over the past decade, since they have the potential to form an excellent biointerface for living cells and tissues. The aim was to determine multiple aspects of the biocompatibility of selected organic semiconductors with high conductivity and to further improve their potential for cell cultivation. Two representatives of low-molecular weight organic semiconductors triisopropylsilyethynyl pentacene (TIPS-Pentacene) and diketopyrrolopyrrole (DPP(TBFu)2) were selected together with two semiconducting organic polymers poly(3-hexylthiophene-2,5-diyl) (P3HT) and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS). The stability of these materials in physiological environment and their wetting properties, which are preconditions for biocompatibility, were determined. TIPS-Pentacene, DPP(TBFu)2 and P3HT were stable but PEDOT:PPS produced some leachates. Native TIPS-Pentacene, DPP(TBFu)2 and P3HT exhibited lowered wettability. Their biocompatibility was studied by means of fibroblasts and differentiated cardiomyocytes. It was limited compared to standard cell culture plastics, thus coating of surface by proteins was applied. Among others collagen IV coating was shown to significantly improve biocompatibility of all tested organic semiconductors. Finally, cultures of spontaneously beating cardiomyocytes were established on TIPS-Pentacene, DPP(TBFu)2, P3HT and PEDOT:PSS.

Keywords

Organic semiconductorStabilityCell viabilityBiocompatibilityFibroblastsCardiomyocytes

Authors

ŠAFAŘÍKOVÁ, E.; ŠINDLEROVÁ, L.; STŘÍTESKÝ, S.; KUBALA, L.; VALA, M.; WEITER, M.; VÍTEČEK, J.

Released

18. 12. 2017

Publisher

ELSEVIER SCIENCE SA

Location

LAUSANNE, SWITZERLAND

ISBN

0925-4005

Periodical

Sensors and Actuators B: Chemical

Number

260

State

Swiss Confederation

Pages from

418

Pages to

425

Pages count

BibTex

@article{BUT145994,
  author="ŠAFAŘÍKOVÁ, E. and ŠINDLEROVÁ, L. and STŘÍTESKÝ, S. and KUBALA, L. and VALA, M. and WEITER, M. and VÍTEČEK, J.",
  title="Evaluation and improvement of organic semiconductors’ biocompatibility towards fibroblasts and cardiomyocytes",
  journal="Sensors and Actuators B: Chemical",
  year="2017",
  number="260",
  pages="418--425",
  doi="10.1016/j.snb.2017.12.108",
  issn="0925-4005"
}