Publication detail

Interactions of hyaluronan with oppositely charged surfactants in very diluted solutions in water

PILGROVÁ, T. VENEROVÁ, T. MRAVEC, F. PEKAŘ, M.

Original Title

Interactions of hyaluronan with oppositely charged surfactants in very diluted solutions in water

Type

journal article in Web of Science

Language

English

Original Abstract

The phase behavior of aqueous systems containing hyaluronan, at concentrations between 2 to 100 mg/L, and oppositely charged surfactants was investigated. A fluorescence probe technique revealed the formation of micellar structures on the hyaluronan in homogeneous systems well below the surfactant standard, critical, micellar concentration. Moreover, regions of gel-phase separation were revealed. A detailed phase diagram was, thus, constructed in the very diluted region and the hyaluronan concentration was found to be the main parameter controlling the phase behavior, in contrast to the charge ratio. The stability of hyaluronan-surfactant aggregates in the homogeneous systems while in storage at 4 °C (up to three months), against dilution, salt addition and on heating-cooling (between 10 and 50 °C) was also investigated. The aggregates were stable while in storage or upon increasing and decreasing the temperature. The dilution of hyaluronan-surfactant complexes or the addition of 0.15 M NaCl led to their disintegration. Finally, systems prepared in a 0.15 M NaCl solution showed that interactions are suppressed and no aggregation below the standard critical micellar concentration was observed.

Keywords

hyaluronan; interactions; surfactants

Authors

PILGROVÁ, T.; VENEROVÁ, T.; MRAVEC, F.; PEKAŘ, M.

Released

1. 2. 2018

ISBN

0141-8130

Periodical

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Year of study

112

Number

1

State

Kingdom of the Netherlands

Pages from

241

Pages to

249

Pages count

9

URL

https://doi.org/10.1016/j.ijbiomac.2018.01.176

BibTex

@article{BUT145670,
  author="Tereza {Pilgrová} and Tereza {Venerová} and Filip {Mravec} and Miloslav {Pekař}",
  title="Interactions of hyaluronan with oppositely charged surfactants in very
diluted solutions in water",
  journal="INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES",
  year="2018",
  volume="112",
  number="1",
  pages="241--249",
  doi="10.1016/j.ijbiomac.2018.01.176",
  issn="0141-8130",
  url="https://doi.org/10.1016/j.ijbiomac.2018.01.176"
}