Publication detail

Hyaluronan hydrogels modified by glycinated Kraft lignin: Morphology, swelling, viscoelastic properties and biocompatibility

Lenka Musilová, Aleš Mráček, Adriana Kovalcik, Petr Smolka, Antonín Minařík, Petr Humpolíček, Robert Vícha, Petr Ponížil

Original Title

Hyaluronan hydrogels modified by glycinated Kraft lignin: Morphology, swelling, viscoelastic properties and biocompatibility

Type

journal article in Web of Science

Language

English

Original Abstract

Effects of the addition of water soluble glycinated Kraft lignin (WS/KL) on the mechanical stability and biocompatibility of hyaluronan (NaHy) hydrogels were evaluated in this work. Water soluble lignin was obtained by the modification of Kraft lignin via a Mannich reaction. It was found that WS/KL is highly compatible with hyaluronan due to its improved water solubility, which favours its use in designing new advanced composite hydrogels. The effects of the concentration of WS/KL on morphological, swelling and creep/recovery behaviours of hyaluronan hydrogels were investigated. It was detected that the creep resistance and creep recovery of NaHy hydrogels was improved by the incorporation of up to 3% (w/w) of WS/KL. In contrast, the swelling capacity of hydrogels was decreased. The cytotoxicity tests proved that glycinated KL lignin limits the viability of cells only slightly, and the final hyaluronan/lignin hydrogels were non-toxic materials.

Keywords

Hyaluronan Lignin Hydrogel Swelling behaviour Mechanical properties Biocompatibility of hydrogels

Authors

Lenka Musilová, Aleš Mráček, Adriana Kovalcik, Petr Smolka, Antonín Minařík, Petr Humpolíček, Robert Vícha, Petr Ponížil

Released

1. 1. 2018

Publisher

Elsevier

Location

Amsterdam

ISBN

1879-1344

Periodical

Carbohydrate Polymers (electronic)

Year of study

181

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

394

Pages to

403

Pages count

10

URL

http://www.sciencedirect.com/science/article/pii/S0144861717311918

BibTex

@article{BUT141040,
  author="Adriána {Kovalčík}",
  title="Hyaluronan hydrogels modified by glycinated Kraft lignin: Morphology,
swelling, viscoelastic properties and biocompatibility",
  journal="Carbohydrate Polymers (electronic)",
  year="2018",
  volume="181",
  number="1",
  pages="394--403",
  doi="10.1016/j.carbpol.2017.10.048",
  issn="1879-1344",
  url="http://www.sciencedirect.com/science/article/pii/S0144861717311918"
}