Publication detail

Fluorescence study of freeze-drying as a method for support the interactions between hyaluronan and hydrophobic species

MICHALICOVÁ, P. MRAVEC, F. PEKAŘ, M.

Original Title

Fluorescence study of freeze-drying as a method for support the interactions between hyaluronan and hydrophobic species

Type

journal article in Web of Science

Language

English

Original Abstract

A freeze-drying method enabling solubilization of hydrophobic species in aqueous solutions of native hyaluronan is described. The method is based on opening the access to supposed hydrophobic patches on hyaluronan by disturbing its massive hydration shell. Hydrophobic and/or polarity-sensitive fluorescence probes were used as hydrophobic models or indicators of interactions with hydrophobic patches. Fluorescence parameters specific to individual probes confirmed the efficiency of the freeze-drying method. This work is the first step in developing biocompatible and biodegradable carriers for hydrophobic drugs with targeted distribution of the active compound from native, chemically non-modified hyaluronan.

Keywords

fluorescence; freeze-drying; hyaluronan; solubilization

Authors

MICHALICOVÁ, P.; MRAVEC, F.; PEKAŘ, M.

Released

3. 10. 2017

Publisher

PLOS

ISBN

1932-6203

Periodical

PLOS ONE

Year of study

12

Number

9

State

United States of America

Pages from

1

Pages to

13

Pages count

13

URL

http://europepmc.org/articles/PMC5590968?pdf=render

Full text in the Digital Library

http://hdl.handle.net/11012/84116

BibTex

@article{BUT141013,
  author="Petra {Michalicová} and Filip {Mravec} and Miloslav {Pekař}",
  title="Fluorescence study of freeze-drying as a method for support the interactions between hyaluronan and hydrophobic species",
  journal="PLOS ONE",
  year="2017",
  volume="12",
  number="9",
  pages="1--13",
  doi="10.1371/journal.pone.0184558",
  issn="1932-6203",
  url="http://europepmc.org/articles/PMC5590968?pdf=render"
}