Hydrogels based on cationic polyelectrolytes

conference paper

English

The main aim of this work is laboratory preparation and characterization of hydrogels based on cationic polyelectrolytes. Cationic polyelectrolytes can interact with oppositely charged surfactants via electrostatic forces. Interactions between cationic polyelectrolytes and anionic surfactants can generate physical gels (under proper conditions such as temperature, pH, ionic strenght) and surfactants are able to form micellar structures suitable for solubilizing hydrophobic compounds in aqueous environment of the gel. Resulting materials are hydrogels which contain hydrophobic nanodomains so it is possible to use like porters in drug delivery in medicine, e.g. hydrophobic drugs for topical applications (wound healing and so on). The presence of hydrophobic nanodomains was tested by solubilization tests with the help of hydrophobic dyes (e.g. Oil red O, prodan). Mechanical properties of prepared materials were tested rheologically (in dependence of their composition). This work is focused on the preparation of gels from positively charged polysaccharides dextran hydrochloride and negatively charged surfactant sodium dodecyl sulphate.

hydrogel, polyelectrolyte, surfactant, nanodomain, micelles, rheology, solubilization test

JARÁBKOVÁ, S.; MRAVEC, F.; SMILEK, J.; PEKAŘ, M.

23. 3. 2017

Vysoké učení technické v Brně, Fakulta chemická

Brno

978-80-214-5489-7

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první

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