Publication detail

Determination of macrolide antibiotics in three different wastewater treatment plants

LANDOVÁ, P. VÁVROVÁ, M.

Original Title

Type

conference proceedings

Language

English

Original Abstract

Antibiotics are drugs used in human and veterinary practice to treat diseases caused by microorganisms and they may also serve as growth promoters for livestock in veterinary medicine. After administration, the drugs are excreted from the body in the form of inactive metabolites or unchanged via urine or feces. These substances are then discharged into the wastewater and in most cases enter the wastewater treatment plants (WWTPs). Antibiotics can negatively affect biological processes of treatment, where microorganisms are essential for a proper functioning wastewater treatment plant. As has already been reported many times, the efficiency of antibiotics removal is not sufficient, thus WWTPs are considered as major point sources of environmental contamination by these compounds. Wastewater from three different types of WWTPs was tested on the content of four macrolides: azithromycin, clarithromycin, erythromycin and roxithromycin. The analytical method combined solid phase extraction followed by a chromatographic separation using hydrophilic interaction liquid chromatography coupled to an ion trap mass spectrometer. All target antibiotics were detected in 100 % of the collected raw influent samples with concentrations varied from 15 to 1849 ng L-1. Azithromycin, clarithromycin, and erythromycin were also detected in 100 % of the treated water samples and roxithromycin was present in 96 % of samples. Based on determined macrolide concentrations, removal efficiencies of individual wastewater treatment plants were calculated, ranging from 13 to 100 %.

Keywords

wastewater; macrolide antibiotics; HPLC/MS; SPE

Authors

LANDOVÁ, P.; VÁVROVÁ, M.

Released

4. 4. 2017

Location

Petrohrad

Pages from

439

Pages to

439

Pages count

614

BibTex

@proceedings{BUT138231,
  editor="Pavlína {Landová} and Milada {Vávrová}",
  title="Determination of macrolide antibiotics in three different wastewater treatment plants",
  year="2017",
  pages="439--439",
  address="Petrohrad"
}