Publication detail

Occurence of Macrolide Antibiotics in Waste Water

LANDOVÁ, P. VÁVROVÁ, M.

Original Title

Type

presentation

Language

English

Original Abstract

Antibiotics are pharmaceuticals used to treat diseases caused by bacteria. They are widely used in human and veterinary medicine. Macrolides are after penicillins the second most prescribed group of antibiotics in the Czech Republic. After administration, the drugs are excreted from the body in the form of metabolites or unchanged via urine or feces. These compounds are then discharged into the waste water and in most cases enter the wastewater treatment plants (WWTPs). Antibiotic can negatively affect biological processes of treatment, where microorganisms are essential for proper functioning WWTP. In many cases the efficiency of antibiotics removal is not sufficient, thus WWTPs are considered as major point sources of environmental contamination by these compounds. The presence of antibiotics in the environment can lead to the development of bacterial resistance to antibiotics which is one of the biggest threats to mankind nowadays. In this work, we examined the presence of macrolide antibiotics (azithromycin, clarithromycin, erythromycin and roxithromycin) in waste water (in both, inflow and outflow from treatment plant) from three different WWTPs – WWTP Brno-Modřice, WWTP Mikulov and WWTP of The University of Veterinary and Pharmaceutical Sciences Brno. As pre-concentration step was used solid phase extraction (SPE) and HPLC coupled to MS detection was used as a final analytical technique. The total occurrence of macrolides in 26 collected samples was 100 % for azithromycin, clarithromycin and erythromycin and 96 % for roxithromycin. In general, the highest concentrations were observed in WWTP of Brno-Modřice and the lowest concentrations were determined in WWTP of The University of Veterinary and Pharmaceutical Sciences Brno. The comparison of concentrations of individual substances shows, that the concentrations of azithromycin and clarithromycin were one or two orders of magnitude higher than the concentrations of erythromycin and roxithromycin (concentration scale of ng L-1 to μg L-1). Calculated removal efficiencies of antibiotics were ranging from 13 to 100 %.

Keywords

waste water; macrolide antibiotics; liquid chromatography; mass spectrometry; solid phase extraction

Authors

LANDOVÁ, P.; VÁVROVÁ, M.

Released

23. 3. 2017

Location

Brno

Pages from

Pages to

Pages count

BibTex

@misc{BUT138182,
  author="Pavlína {Landová} and Milada {Vávrová}",
  title="Occurence of Macrolide Antibiotics in Waste Water",
  year="2017",
  pages="67--67",
  address="Brno",
  note="presentation"
}