Publication detail

Novel Chitin/chitosan-glucan Wound Dressing: Isolation, Characterization and Medical Applications

ABDEL-LATTIF, A. HRDINA, R. HEBIESH, A. JANČÁŘ, J.

Original Title

Type

presentation

Language

English

Original Abstract

Chitin/chitosan-glucan complex (ChCsGC) was isolated from schizophyllum commune (S. commune) and dissolved for the first time in precooled (-15 °C) 8 wt. % urea/6 wt. % NaOH aqueous solution. Novel nonwoven microfiber mats were fabricated by wet-dry-spinning technique and evaluated the mechanical and surface morphology. Prepared materials were characterized employing FTIR-ATR, Optical microscope, TGA, DSC, H/C-NMR, SEM and XRD techniques. The biological activity of the nonwoven ChCsGC fabric was tested against Escherichia coli (E.coli) bacteria exhibiting excellent antibacterial activity. The cell viability of the extracted complex and nonwovens were evaluated utilizing mouse fibroblast cell line varying concentration and treatment time. ChCsGC didn’t show any cytotoxicity against mouse fibroblast cells. The novel ChCsGC nonwovens exhibited excellent surgical wound healing ability of when tested using rat models.

Keywords

Chitin/chitosan-glucan complex, nonwoven mat, surgical wound healing

Authors

ABDEL-LATTIF, A.; HRDINA, R.; HEBIESH, A.; JANČÁŘ, J.

Released

14. 6. 2016

ISBN

978-80-86238-82-1

BibTex

@misc{BUT126928,
  author="Abdelmohsen Moustafa {Abdellatif} and Radim {Hrdina} and ali {hebiesh} and Josef {Jančář}",
  title="Novel Chitin/chitosan-glucan Wound Dressing: Isolation, Characterization and Medical Applications",
  year="2016",
  isbn="978-80-86238-82-1",
  note="presentation"
}