Publication detail
Synthesis of Some Biologically Active Pyrazolylphthalazine Derivatives and Acyclo-C-nucleosides of 6-(2,4,6-trimethylphenyl)-1,2,4-triazolo[3,4-a]phthalazine
EL-SHAMY, I. ABDEL-LATTIF, A. FOUDA, M. AL-DEYAB, S. EL-HASHASH, M.
Original Title
Synthesis of Some Biologically Active Pyrazolylphthalazine Derivatives and Acyclo-C-nucleosides of 6-(2,4,6-trimethylphenyl)-1,2,4-triazolo[3,4-a]phthalazine
Type
journal article in Web of Science
Language
English
Original Abstract
1-Chloro-4-(2,4,6-trimethylphenyl)phthalazine (2) was used as a precursor for preparation of some novel pyrazolylphthalazine derivatives 6-13 and 15-19. Moreover, the acyclonucleosides 20-23 a-e were prepared by the reaction of hydrazinophthalazine derivative 3 with different aldoses. All new phthalazine derivatives were characterized using 1H NMR, 13C NMR, FTIR, mass spectrum and elemental analysis. The newly synthesized compounds showed highly activity against different species of bacteria and fungi, in addition to an excellent antiinflammatory property.
Keywords
C-nucleosides, Phthalazine derivatives, Biological activity
Authors
EL-SHAMY, I.; ABDEL-LATTIF, A.; FOUDA, M.; AL-DEYAB, S.; EL-HASHASH, M.
RIV year
2014
Released
1. 7. 2014
ISBN
0970-7077
Periodical
ASIAN JOURNAL OF CHEMISTRY
Year of study
26
Number
14
State
Republic of India
Pages from
4405
Pages to
4415
Pages count
11
BibTex
@article{BUT112240,
author="Ibrahim E. {El-Shamy} and Abdelmohsen Moustafa {Abdellatif} and Moustafa M.D. {Fouda} and Salem S. {Al-Deyab} and Maher A. {El-Hashash}",
title="Synthesis of Some Biologically Active Pyrazolylphthalazine Derivatives and Acyclo-C-nucleosides of 6-(2,4,6-trimethylphenyl)-1,2,4-triazolo[3,4-a]phthalazine",
journal="ASIAN JOURNAL OF CHEMISTRY",
year="2014",
volume="26",
number="14",
pages="4405--4415",
issn="0970-7077"
}