Publication detail

STUDY OF NANOPARTICLES FORMED BY NEGATIVELY CHARGED HYALURONAN AND CATIONIC SURFACTANTS USING LIGHT SCATTERING TECHNIQUES

PILGROVÁ, T. PEKAŘ, M.

Original Title

Type

abstract

Language

English

Original Abstract

Negatively charged hyaluronan binds to cationic surfactant via electrostatic interactions which result in self-assembly nanoparticles formation. These particles have a core-shell like structure and can be used in targeted drug delivery of hydrophobic active substances. The aim of our study was to prepare and study these systems using dynamic light scattering methods. Titration experiments (size distribution and zeta potential measurements) were utilized to explore the formation of aggregates. Hyaluronan or surfactant was used as titrant for comparison of two preparation methods of these systems. Effect of molecular weight and concentration of hyaluronan were investigated. Aggregates formation is influenced by preparation of systems. Different types of particles are formed if hyaluronan is added to surfactant solution or vice versa. If hyaluronan have a role of titrant, final particles are smaller than in the case of surfactant as titrant and can be more suitable for drug delivery applications.

Keywords

hyaluronan, surfactant, dynamic light scattering

Authors

PILGROVÁ, T.; PEKAŘ, M.

Released

22. 9. 2014

Location

Faculty of Physics, University of Vienna, Austria

Pages from

Pages to

Pages count

BibTex

@misc{BUT109570,
  author="Tereza {Pilgrová} and Miloslav {Pekař}",
  title="STUDY OF NANOPARTICLES FORMED BY NEGATIVELY CHARGED HYALURONAN AND CATIONIC SURFACTANTS USING LIGHT SCATTERING TECHNIQUES",
  year="2014",
  pages="1",
  address="Faculty of Physics, University of Vienna, Austria",
  note="abstract"
}