Publication detail

Study of Nanoparticles Formed by Negatively Charged Hyaluronan and Cationic Surfactant

KRUTIŠOVÁ, T. PEKAŘ, M.

Original Title

Type

conference paper

Language

English

Original Abstract

Negatively charged hyaluronan binds to cationic surfactant via electrostatic interactions which result in self-assembly nanoparticles formation. The aim of study was to prepare and study hyaluronic acid nanoparticles based on electrostatic interactions with oppositely charged surfactant molecules. Aggregates formation is influenced by preparation of systems. Different types of particles are formed if hyaluronan is added to surfactant solution or vice versa. If hyaluronan have a role of titrant, final particles are smaller than in the case of surfactant as titrant and can be more suitable for drug delivery applications. Assuming in the isoelectric point is reached compensation of charges of hyaluronan and surfactant, real degrees of hyaluronan dissociation were determined. Concentration of hyaluronan and conformation of hyaluronan in the system have a significant effect on established degree of dissociation.

Keywords

hyaluronan, surfactant, nanoparticles

Authors

KRUTIŠOVÁ, T.; PEKAŘ, M.

RIV year

2014

Released

3. 6. 2014

ISBN

978-80-210-6842-1

Book

XIV. pracovní setkání fyzikálních chemiků a elektrochemiků, sborník příspěvků

Pages from

Pages to

Pages count

BibTex

@inproceedings{BUT107804,
  author="Tereza {Pilgrová} and Miloslav {Pekař}",
  title="Study of Nanoparticles Formed by Negatively Charged Hyaluronan and Cationic Surfactant",
  booktitle="XIV. pracovní setkání fyzikálních chemiků a elektrochemiků, sborník příspěvků",
  year="2014",
  pages="73--77",
  isbn="978-80-210-6842-1"
}