Publication detail

Synthesis, characterization and antibacterial activity of new fluorescent chitosan derivatives

PŘICHYSTALOVÁ, H. ALMONASY, N. ABDEL-LATTIF, A. ABDEL-RAHMAN, R. FOUDA, M. VOJTOVÁ, L. KOBĚRA, L. SPOTZ, Z. BURGERT, L. JANČÁŘ, J.

Original Title

Type

journal article in Web of Science

Language

English

Original Abstract

The present work aims to the development of innovative new derivatives of chitosan that can be used for medical applications. This innovation is based on the synthesis and characterization of chitosan-g-aminoanthracene derivatives. Thus, N-(anthracen-9-yl)-4,6- dichloro-[1,3,5]-triazin-2-amine (AT) reacted with chitosan by the following steps: At first, cyanuric chloride reacted with 9-aminoanthracene to obtain N-(anthracen-9-yl)-4,6-dichloro- 40 [1,3,5]-triazin-2-amine (AT), then the AT reacted with chitosan to obtain (CH -g-AT). The final product of CH-g-AT was separated, purified and re-crystallized by dioxan. The structure of the prepared chitosan derivatives was confirmed by FTIR-ATR, solid-NMR, TGA, X-RD, and DSC. The new chitosan derivatives showed fluorescence spectra in liquid and in solid state as well. CH-g-AT showed also high antibacterial activity against gram-negative species (Escherichia coli).

Keywords

chitosan, antibacterial activity, fluorescent derivatives

Authors

PŘICHYSTALOVÁ, H.; ALMONASY, N.; ABDEL-LATTIF, A.; ABDEL-RAHMAN, R.; FOUDA, M.; VOJTOVÁ, L.; KOBĚRA, L.; SPOTZ, Z.; BURGERT, L.; JANČÁŘ, J.

RIV year

2014

Released

1. 4. 2014

ISBN

0141-8130

Periodical

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Year of study

Number

State

Kingdom of the Netherlands

Pages from

234

Pages to

240

Pages count

580

BibTex

@article{BUT105081,
  author="Hana {Přichystalová} and Numan {Almonasy} and Abdelmohsen Moustafa {Abdellatif} and Rasha M. {Abdel-Rahman} and Moustafa M.D. {Fouda} and Lucy {Vojtová} and Libor {Koběra} and Zdeněk {Spotz} and Ladislav {Burgert} and Josef {Jančář}",
  title="Synthesis, characterization and antibacterial activity of new fluorescent chitosan derivatives",
  journal="INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES",
  year="2014",
  volume="65",
  number="1",
  pages="234--240",
  doi="10.1016/j.ijbiomac.2014.01.050",
  issn="0141-8130"
}