This project aims to mechanically characterize the complex structure of hydrogel-infiltrated scaffolds to develop an in vitro model of the bone marrow niche. 3D printed scaffolds based on titanium and hydroxyapatite will reproduce the endosteal niche of the bone marrow, while interpenetrating and semi-interpenetrating polymer networks will mimic the reticular niche. In vitro model of the bone marrow could contribute to the development of treatment approaches for various hematopoietic diseases, such as leukaemia or anaemia.

CEITEC VUT/FCH-J-23-8367

Czech

Drotárová Lenka, Ing. - principal person responsible
Montufar Jimenez Edgar Benjamin, M.Sc., Ph.D. - fellow researcher
Sedláček Petr, doc. Ing., Ph.D. - fellow researcher
Zahrádka Jan, Ing. - fellow researcher

Advanced Coatings
- responsible department (6.3.2023 - not assigned)
Central European Institute of Technology BUT
- responsible department (30.1.2023 - 6.3.2023)
Advanced Coatings
- beneficiary (1.1.2023 - 31.12.2023)
Institute of Physical and Applied Chemistry
- beneficiary (1.1.2023 - 31.12.2023)

DROTÁROVÁ, L.; SLÁMEČKA, K.; BALINT, M.; REMEŠOVÁ, M.; HUDÁK, R.; ŽIVČÁK, J.; ČELKO, L.; MONTUFAR JIMENEZ, E. Biodegradable WE43 Mg alloy/hydroxyapatite interpenetrating phase composites with reduced hydrogen evolution. Bioactive Materials, 2024, vol. 42, no. 12, p. 519-530. ISSN: 2452-199X.
Detail

OLIVER URRUTIA, C.; DROTÁROVÁ, L.; GASCÓN-PÉREZ, S.; SLÁMEČKA, K.; RAVASZOVÁ, S.; ČELKO, L.; MONTUFAR JIMENEZ, E. Hydroxyapatite-Resin Composites Produced by Vat Photopolymerization and Post-Processing via In Situ Hydrolysis of Alpha Tricalcium Phosphate. Ceramics-Switzerland, 2023, vol. 6, no. 4, p. 2282-2294. ISSN: 2571-6131.
Detail

Responsibility: Drotárová Lenka, Ing.