Detail publikace

Evaluation and improvement of organic semiconductors’ biocompatibility towards fibroblasts and cardiomyocytes

ŠAFAŘÍKOVÁ, E. ŠINDLEROVÁ, L. STŘÍTESKÝ, S. KUBALA, L. VALA, M. WEITER, M. VÍTEČEK, J.

Originální název

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

The use of organic semiconductors in bioelectronic devices has received considerable attention over the past decade, since they have the potential to form an excellent biointerface for living cells and tissues. The aim was to determine multiple aspects of the biocompatibility of selected organic semiconductors with high conductivity and to further improve their potential for cell cultivation. Two representatives of low-molecular weight organic semiconductors triisopropylsilyethynyl pentacene (TIPS-Pentacene) and diketopyrrolopyrrole (DPP(TBFu)2) were selected together with two semiconducting organic polymers poly(3-hexylthiophene-2,5-diyl) (P3HT) and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS). The stability of these materials in physiological environment and their wetting properties, which are preconditions for biocompatibility, were determined. TIPS-Pentacene, DPP(TBFu)2 and P3HT were stable but PEDOT:PPS produced some leachates. Native TIPS-Pentacene, DPP(TBFu)2 and P3HT exhibited lowered wettability. Their biocompatibility was studied by means of fibroblasts and differentiated cardiomyocytes. It was limited compared to standard cell culture plastics, thus coating of surface by proteins was applied. Among others collagen IV coating was shown to significantly improve biocompatibility of all tested organic semiconductors. Finally, cultures of spontaneously beating cardiomyocytes were established on TIPS-Pentacene, DPP(TBFu)2, P3HT and PEDOT:PSS.

Klíčová slova

Organic semiconductorStabilityCell viabilityBiocompatibilityFibroblastsCardiomyocytes

Autoři

ŠAFAŘÍKOVÁ, E.; ŠINDLEROVÁ, L.; STŘÍTESKÝ, S.; KUBALA, L.; VALA, M.; WEITER, M.; VÍTEČEK, J.

Vydáno

18. 12. 2017

Nakladatel

ELSEVIER SCIENCE SA

Místo

LAUSANNE, SWITZERLAND

ISSN

0925-4005

Periodikum

Sensors and Actuators B: Chemical

Číslo

260

Stát

Švýcarská konfederace

Strany od

418

Strany do

425

Strany počet

BibTex

@article{BUT145994,
  author="ŠAFAŘÍKOVÁ, E. and ŠINDLEROVÁ, L. and STŘÍTESKÝ, S. and KUBALA, L. and VALA, M. and WEITER, M. and VÍTEČEK, J.",
  title="Evaluation and improvement of organic semiconductors’ biocompatibility towards fibroblasts and cardiomyocytes",
  journal="Sensors and Actuators B: Chemical",
  year="2017",
  number="260",
  pages="418--425",
  doi="10.1016/j.snb.2017.12.108",
  issn="0925-4005"
}