Detail publikace

Replica-mold nanopatterned PHEMA hydrogel surfaces for ophthalmic applications

KRAJŇÁK, T. ČERNÁ, E. ŠURÁŇOVÁ, M. ŠAMOŘIL, T. ZICHA, D. VOJTOVÁ, L. ČECHAL, J.

Originální název

Replica-mold nanopatterned PHEMA hydrogel surfaces for ophthalmic applications

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Biomimicking native tissues and organs require the development of advanced hydrogels. The patterning of hydrogel surfaces may enhance the cellular functionality and therapeutic efficacy of implants. For example, nanopatterning of the intraocular lens (IOL) surface can suppress the upregulation of cytoskeleton proteins (actin and actinin) within the cells in contact with the IOL surface and, hence, prevent secondary cataracts causing blurry or opaque vision. Here we introduce a fast and efficient method for fabricating arrays consisting of millions of individual nanostructures on the hydrogel surface. In particular, we have prepared the randomly distributed nanopillars on poly(2-hydroxyethyl methacrylate) hydrogel using replica molding and show that the number, shape, and arrangement of nanostructures are fully adjustable. Characterization by atomic force microscopy revealed that all nanopillars were of similar shape, narrow size distribution, and without significant defects. In imprint lithography, choosing the appropriate hydrogel composition is critical. As hydrogels with imprinted nanostructures mimic the natural cell environment, they can find applications in fundamental cell biology research, e.g., they can tune cell attachment and inhibit or promote cell clustering by a specific arrangement of protrusive nanostructures on the hydrogel surface.

Klíčová slova

Nanopattern, AFM, FIB-SEM, XPS, secondary cataracts, intraocular lens, PHEMA

Autoři

KRAJŇÁK, T.; ČERNÁ, E.; ŠURÁŇOVÁ, M.; ŠAMOŘIL, T.; ZICHA, D.; VOJTOVÁ, L.; ČECHAL, J.

Vydáno

25. 8. 2022

Nakladatel

NATURE PORTFOLIO

Místo

BERLIN

ISSN

2045-2322

Periodikum

Scientific Reports

Ročník

12

Číslo

1

Stát

Spojené království Velké Británie a Severního Irska

Strany od

14497

Strany do

14506

Strany počet

10

URL

https://www.nature.com/articles/s41598-022-18564-3

BibTex

@article{BUT179586,
  author="Tomáš {Krajňák} and Eva {Černá} and Markéta {Šuráňová} and Tomáš {Šamořil} and Daniel {Zicha} and Lucy {Vojtová} and Jan {Čechal}",
  title="Replica-mold nanopatterned PHEMA hydrogel surfaces for ophthalmic applications",
  journal="Scientific Reports",
  year="2022",
  volume="12",
  number="1",
  pages="10",
  doi="10.1038/s41598-022-18564-3",
  issn="2045-2322",
  url="https://www.nature.com/articles/s41598-022-18564-3"
}