Detail publikace

Tailoring the internal microstructue of the hydrogels based on poly-HEMA targeted for drug delivery systems

TRUDIČOVÁ, M. PAPEŽÍKOVÁ, H. SEDLÁČEK, P. PEKAŘ, M.

Originální název

Tailoring the internal microstructue of the hydrogels based on poly-HEMA targeted for drug delivery systems

Typ

článek ve sborníku ve WoS nebo Scopus

Jazyk

angličtina

Originální abstrakt

The transport and barrier properties are important material characteristics in terms of the development of the targeted drug delivery systems. Therefore, this work focused on the study of the possibility of influencing these properties and internal architecture in a model hydrogel system formed by a semi-interpenetrating polymer network with an incorporated polyelectrolyte component. Due to its application potential and its extensive use in medicine, poly(2-hydroxyethyl methacrylate) was chosen as the model hydrogel system for this work. Sodium polystyrene sulfonate was used as the interpenetrating linear polymer. Scanning electron microscopy was used to examine the structure of the three-dimensional hydrogel network. Transport properties were monitored by diffusion tests. Furthermore, diffusion through the hydrogel (barrier properties) was monitored using diffusion cells (Franz cells, horizontal cells). The usability of the semi-interpenetrating polymer network concept for the preparation of materials with tunable relevant properties was confirmed on the proposed materials.

Klíčová slova

hydrogel, poly(2-hydroxyethyl methacrylate), transport properties, drug delivery systems

Autoři

TRUDIČOVÁ, M.; PAPEŽÍKOVÁ, H.; SEDLÁČEK, P.; PEKAŘ, M.

Vydáno

1. 1. 2022

Nakladatel

TANGER Ltd.

Místo

Ostrava

ISBN

978-80-88365-00-6

Kniha

CONFERENCE PROCEEDINGS - NANOCON 2021

Strany od

280

Strany do

285

Strany počet

6

URL

https://www.confer.cz/nanocon/2021/4350-tailoring-the-internal-microstructure-of-the-hydrogels-based-on-poly-hema-targeted-for-drug-delivery-systems

Plný text v Digitální knihovně

http://hdl.handle.net/11012/208761

BibTex

@inproceedings{BUT179527,
  author="Monika {Trudičová} and Hana {Papežíková} and Petr {Sedláček} and Miloslav {Pekař}",
  title="Tailoring the internal microstructue of the hydrogels based on poly-HEMA targeted for drug delivery systems",
  booktitle="CONFERENCE PROCEEDINGS - NANOCON 2021",
  year="2022",
  pages="280--285",
  publisher="TANGER Ltd.",
  address="Ostrava",
  doi="10.37904/nanocon.2021.4350",
  isbn="978-80-88365-00-6",
  url="https://www.confer.cz/nanocon/2021/4350-tailoring-the-internal-microstructure-of-the-hydrogels-based-on-poly-hema-targeted-for-drug-delivery-systems"
}