Detail publikace

Macroporous bioceramic scaffolds based on tricalcium phosphates reinforced with silica: microstructural, mechanical, and biological evaluation

NOVOTNÁ, L. CHLUP, Z. JAROŠ, J. ČÁSTKOVÁ, K. DRDLÍK, D. POSPÍŠIL, J. HAMPL, A. KOUTNÁ, I. CIHLÁŘ, J.

Originální název

Macroporous bioceramic scaffolds based on tricalcium phosphates reinforced with silica: microstructural, mechanical, and biological evaluation

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

The positive effect of silica on microstructural, mechanical and biological properties of calcium phosphate scaffolds was investigated in this study. Scaffolds containing 3D interconnected spherical macropores with diameters in the range of 300-770 mu m were prepared by the polymer replica technique. Reinforcement was achieved by incorporating 5 to 20 wt % of colloidal silica into the initial hydroxyapatite (HA) powder. The HA was fully decomposed into alpha and beta-tricalcium phosphate, and silica was transformed into cristobalite at 1200 degrees C. Silica reinforced scaffolds exhibited compressive strength in the range of 0.3 to 30 MPa at the total porosity of 98-40%. At a nominal porosity of 75%, the compressive strength was doubled compared to scaffolds without silica. When immersed into a cultivation medium, the formation of an apatite layer on the surfaces of scaffolds indicated their bioactivity. The supportive effect of the silicon enriched scaffolds was examined using three different types of cells (human adipose-derived stromal cells, L929, and ARPE-19 cells). The cells firmly adhered to the surfaces of composite scaffolds with no sign of induced cell death. Scaffolds were non-cytotoxic and had good biocompatibility in vitro. They are promising candidates for therapeutic applications in regenerative medicine.

Klíčová slova

Bioceramics; scaffold; calcium phosphate; silica; compressive strength

Autoři

NOVOTNÁ, L.; CHLUP, Z.; JAROŠ, J.; ČÁSTKOVÁ, K.; DRDLÍK, D.; POSPÍŠIL, J.; HAMPL, A.; KOUTNÁ, I.; CIHLÁŘ, J.

Vydáno

27. 3. 2022

Nakladatel

Informa

Místo

ABINGDON

ISSN

2187-0764

Periodikum

Journal of Asian Ceramic Societies

Ročník

10

Číslo

2

Stát

Japonsko

Strany od

356

Strany do

369

Strany počet

14

URL

https://www.tandfonline.com/doi/full/10.1080/21870764.2022.2053278

Plný text v Digitální knihovně

http://hdl.handle.net/11012/204117

BibTex

@article{BUT177591,
  author="Lenka {Novotná} and Zdeněk {Chlup} and Josef {Jaroš} and Klára {Částková} and Daniel {Drdlík} and Jakub {Pospíšil} and Aleš {Hampl} and Irena {Koutná} and Jaroslav {Cihlář}",
  title="Macroporous bioceramic scaffolds based on tricalcium phosphates reinforced with silica: microstructural, mechanical, and biological evaluation",
  journal="Journal of Asian Ceramic Societies",
  year="2022",
  volume="10",
  number="2",
  pages="356--369",
  doi="10.1080/21870764.2022.2053278",
  issn="2187-0764",
  url="https://www.tandfonline.com/doi/full/10.1080/21870764.2022.2053278"
}