Detail publikace

Chitosan-Glucan Complex Hollow Fibers Reinforced Collagen Wound Dressing Embedded with Aloe vera. II. Multifunctional Properties to Promote Cutaneous Wound Healing

ABDELLATIF, A. JANČÁŘ, J. ABDEL-RAHMAN, R. KUBENA, I. FRANKOVA, J. SALEM, A. SAHAFFIE, N.

Originální název

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

This study presents an innovative multifunctional system in fabricating new functional wound dressing (FWD) products that could be used for skin regeneration, especially in cases of infected chronic wounds and ulcers. The innovation is based on the extraction, characterization, and application of collagen (CO)/chitosan-glucan complex hollow fibers (CSGC)/aloe vera (AV) as a novel FWS. For the first time, specific hollow fibers were extracted with controlled inner (500-900 nm)/outer (2-3 µm) diameters from mycelium of Schizophyllum commune. Further on, research and evaluation of morphology, hydrolytic stability, and swelling characteristics of CO/CSGC@AV were carried out. The obtained FWS showed high hydrolytic stability with enhanced swelling characteristics compared to native collagen. The hemostatic effect of FWS increased significantly in the presence of CSGC, compared to native CO and displayed excellent biocompatibility which was tested by using normal human dermal fibroblast (NHDF). The FWS showed high antibacterial activity against different types of bacteria (positive/negative grams). From in vivo measurements, the novel FWS increased the percentage of wound closure after one week of treatment. All these results imply that the new CO/CSGC@AV-FWD has the potential for clinical skin regeneration and applying for controlled drug release.

Klíčová slova

Multifunctional wound dressing, hollow fibers, hemostasis, bactericidal performance.

Autoři

ABDELLATIF, A.; JANČÁŘ, J.; ABDEL-RAHMAN, R.; KUBENA, I.; FRANKOVA, J.; SALEM, A.; SAHAFFIE, N.

Vydáno

15. 4. 2020

Nakladatel

Elsevier

ISSN

0378-5173

Periodikum

INTERNATIONAL JOURNAL OF PHARMACEUTICS

Ročník

582

Číslo

120

Stát

Nizozemsko

Strany od

349

Strany do

361

Strany počet

URL

https://www.sciencedirect.com/science/article/pii/S0378517320303331

BibTex

@article{BUT163846,
  author="Abdelmohsen Moustafa {Abdellatif} and jana {frankova} and Rasha {Radwan} and ameria {salem} and nerman {Sahffie} and Ivo {Kuběna} and Josef {Jančář}",
  title="Chitosan-Glucan Complex Hollow Fibers Reinforced Collagen Wound Dressing Embedded with Aloe vera. II. Multifunctional Properties to Promote Cutaneous Wound Healing",
  journal="INTERNATIONAL JOURNAL OF PHARMACEUTICS",
  year="2020",
  volume="582",
  number="120",
  pages="349--361",
  doi="10.1016/j.ijpharm.2020.119349",
  issn="0378-5173",
  url="https://www.sciencedirect.com/science/article/pii/S0378517320303331"
}