Detail publikace

Determination of Metal Ions in the Plasma of Children with Tumour Diseases by Differential Pulse Voltammetry

KENŠOVÁ, R. HYNEK, D. KYNICKÝ, J. NOVOTNÁ, M. ECKSCHLAGER, T. ADAM, V. HUBÁLEK, J. KIZEK, R.

Originální název

Determination of Metal Ions in the Plasma of Children with Tumour Diseases by Differential Pulse Voltammetry

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

The aim of this study was to investigate the interaction between lead ions and ethylenediaminetetraacetic acid (EDTA) in plasma. EDTA is widely used in medicine as anticoagulant agent. Understanding of the influence of EDTA on the electrochemical lead ions determination is very suitable for the determination of lead ions at patients with increased metals levels in body fluids. Further, the changes of metal ions levels (Zn, Cd, Pb and Cu) were monitored in the blood plasma of child patients treated for various oncological diseases. Electrochemical method differential pulse voltammetry with fully automated system and atomic absorption spectrometry was used for determination of the metal ions. It was found an increased amount of metal ions in the blood plasma of patients suffering from cancer disease in comparison with physiological values in healthy people. In these patients there was also found that they have higher levels of metallothionein and the ratio of GSH/GSSG was reduced. These results suggest that tumour diseases cause important changes in the level of ions.

Klíčová slova

Metals; Electrochemical Analysis; Plasma; EDTA; Interaction; Oncological Diseases

Autoři

KENŠOVÁ, R.; HYNEK, D.; KYNICKÝ, J.; NOVOTNÁ, M.; ECKSCHLAGER, T.; ADAM, V.; HUBÁLEK, J.; KIZEK, R.

Rok RIV

2014

Vydáno

1. 8. 2014

Nakladatel

ESG

ISSN

1452-3981

Periodikum

INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE

Ročník

9

Číslo

8

Stát

Srbská republika

Strany od

4675

Strany do

4691

Strany počet

17

URL

http://www.electrochemsci.org/papers/vol9/90804675.pdf

Plný text v Digitální knihovně

http://hdl.handle.net/11012/201446

BibTex

@article{BUT111179,
  author="Renáta {Kenšová} and David {Hynek} and Jindřich {Kynický} and Marie {Novotná} and Tomáš {Eckschlager} and Vojtěch {Adam} and Jaromír {Hubálek} and René {Kizek}",
  title="Determination of Metal Ions in the Plasma of Children with Tumour Diseases by Differential Pulse Voltammetry",
  journal="INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE",
  year="2014",
  volume="9",
  number="8",
  pages="4675--4691",
  issn="1452-3981",
  url="http://www.electrochemsci.org/papers/vol9/90804675.pdf"
}