Detail publikace
Synthesis, biological, anti-inflammatory activities and quantum chemical calculation of some [4-(2, 4, 6-trimethylphenyl)-1(2H)-oxophthalazin-2yl] acetic acid hydrazide derivatives
EL-SHAMY, I. ABDEL-LATTIF, A. AL MAHMOUD ALSHEIKH, A. FOUDA, M. ELDEYAB, S. EL-HASHASH, M. JANČÁŘ, J.
Originální název
Synthesis, biological, anti-inflammatory activities and quantum chemical calculation of some [4-(2, 4, 6-trimethylphenyl)-1(2H)-oxophthalazin-2yl] acetic acid hydrazide derivatives
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
The phthalazine carbohydrazide 2 was prepared and incorporated into the corresponding 1,2,4-triazole and carbamate derivatives. Phthalazine carboxylic acid hydrazide 2 was treated with isatine and cyclohexanone to give the corresponding hydrazone derivatives 16, 19 in good yields. Furthermore, a-amino acid derivative conjugated with 1-oxophthalazine moiety 35 was synthesized by the reaction of the corresponding aizde 28, via the azide-coupling method, with glycine methyl ester. The peptide ester 35 was converted into their orresponding amide 36 by treating with methanolic ammonia. Moreover, 35 was boiled with hydrazine hydrate to afford the corresponding hydrazide 37. Finally, the dipeptide 38 was prepared by coupling of 35 with L-alanine methyl ester. Some of these compounds were screened in vitro for their antimicrobial activity. The energy gap between the highest occupied molecular orbital and lowest unoccupied molecular orbital has been calculated using the theoretical computations to reflect the chemical reactivity and kinetic stability of compounds.
Klíčová slova
Synthesis, Phthalazine, Quantum calculation, Carbohydrazide, Biological, Anti-inflammatory activities
Autoři
EL-SHAMY, I.; ABDEL-LATTIF, A.; AL MAHMOUD ALSHEIKH, A.; FOUDA, M.; ELDEYAB, S.; EL-HASHASH, M.; JANČÁŘ, J.
Rok RIV
2015
Vydáno
15. 2. 2015
ISSN
0143-7208
Periodikum
DYES AND PIGMENTS
Ročník
113
Číslo
357
Stát
Spojené království Velké Británie a Severního Irska
Strany od
357
Strany do
371
Strany počet
15
BibTex
@article{BUT109643,
author="Ibrahim E. {El-Shamy} and Abdelmohsen Moustafa {Abdellatif} and Amer {Al Mahmoud Alsheikh} and Moustafa {Fouda} and Salam {Eldeyab} and Mather {El-hashash} and Josef {Jančář}",
title="Synthesis, biological, anti-inflammatory activities and quantum chemical calculation of some [4-(2, 4, 6-trimethylphenyl)-1(2H)-oxophthalazin-2yl] acetic acid hydrazide derivatives",
journal="DYES AND PIGMENTS",
year="2015",
volume="113",
number="357",
pages="357--371",
doi="10.1016/j.dyepig.2014.08.026",
issn="0143-7208"
}