Detail publikace

Effect of new hydrophobic modification of hyaluronan on its solution properties: evaluation of self-aggregation

CHYTIL, M. PEKAŘ, M.

Originální název

Typ

článek v časopise - ostatní, Jost

Jazyk

angličtina

Originální abstrakt

The effect of a novel hydrophobic modification of hyaluronan (HA) on its solution properties is presented. The modification was carried out by a chemical binding of alkyl chains (C8 and C12) to the HA backbone via its hydroxyl groups, so that the carboxyl groups remained free, which is crucial for HA applications. Surface tension, rheological and viscosity properties of modified HA (HMHA) were studied. The presented HMHA decreased surface tension, , of their solutions and exhibited an aggregation behavior similar to that of sodium dodecylsulfate (SDS). High-molecular weight HMHA of higher degree of substitution (DS) displayed more effective surface activity and shear-thinning behavior than the solutions of low-molecular weight HMHA. The coefficient of the Mark-Houwink-Sakurada plot was very similar for both native and HMHA, supposing that the stiffness of the HA backbone was not remarkably altered by the modification.

Klíčová slova

hyaluronan; hydrophobic modification; surface tension; aggregation; critical concentration; rheology; shear-thinning; viscosity; intrinsic viscosity; coil-overlap concentration; Huggins coefficient

Autoři

CHYTIL, M.; PEKAŘ, M.

Rok RIV

2009

Vydáno

1. 4. 2009

ISSN

0144-8617

Periodikum

Carbohydrate Polymers

Ročník

Číslo

Stát

Spojené království Velké Británie a Severního Irska

Strany od

443

Strany do

448

Strany počet

BibTex

@article{BUT46827,
  author="Martin {Chytil} and Miloslav {Pekař}",
  title="Effect of new hydrophobic modification of hyaluronan on its solution properties: evaluation of self-aggregation",
  journal="Carbohydrate Polymers",
  year="2009",
  volume="76",
  number="3",
  pages="443--448",
  issn="0144-8617"
}