Detail publikace

Biodegradable WE43 Mg alloy/hydroxyapatite interpenetrating phase composites with reduced hydrogen evolution

DROTÁROVÁ, L. SLÁMEČKA, K. BALINT, M. REMEŠOVÁ, M. HUDÁK, R. ŽIVČÁK, J. ČELKO, L. MONTUFAR JIMENEZ, E.

Originální název

Biodegradable WE43 Mg alloy/hydroxyapatite interpenetrating phase composites with reduced hydrogen evolution

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Biodegradable magnesium implants offer a solution for bone repair without the need for implant removal. However, concerns persist regarding peri-implant gas accumulation, which has limited their widespread clinical acceptance. Consequently, there is a need to minimise the mass of magnesium to reduce the total volume of gas generated around the implants. Incorporating porosity is a direct approach to reducing the mass of the implants, but it also decreases the strength and degradation resistance. This study demonstrates that the infiltration of a calcium phosphate cement into an additively manufactured WE43 Mg alloy scaffold with 75 % porosity, followed by hydrothermal treatment, yields biodegradable magnesium/hydroxyapatite interpenetrating phase composites that generate an order of magnitude less hydrogen gas during degradation than WE43 scaffolds. The enhanced degradation resistance results from magnesium passivation, allowing osteoblast proliferation in indirect contact with composites. Additionally, the composites exhibit a compressive strength 1.8 times greater than that of the scaffolds, falling within the upper range of the compressive strength of cancellous bone. These results emphasise the potential of the new biodegradable interpenetrating phase composites for the fabrication of temporary osteosynthesis devices. Optimizing cement hardening and magnesium passivation during hydrothermal processing is crucial for achieving both high compressive strength and low degradation rate.

Klíčová slova

Magnesium; Biodegradable metal; Calcium phosphate cement; Hydroxyapatite; Composite

Autoři

DROTÁROVÁ, L.; SLÁMEČKA, K.; BALINT, M.; REMEŠOVÁ, M.; HUDÁK, R.; ŽIVČÁK, J.; ČELKO, L.; MONTUFAR JIMENEZ, E.

Vydáno

1. 12. 2024

Nakladatel

KEAI PUBLISHING LTD

Místo

BEIJING

ISSN

2452-199X

Periodikum

Bioactive Materials

Ročník

42

Číslo

12

Stát

Čínská lidová republika

Strany od

519

Strany do

530

Strany počet

12

URL

https://www.sciencedirect.com/science/article/pii/S2452199X24003876

BibTex

@article{BUT189829,
  author="Lenka {Drotárová} and Karel {Slámečka} and Tomáš {Bálint} and Michaela {Remešová} and Radovan {Hudák} and Jozef {Živčák} and Marek {Schnitzer} and Ladislav {Čelko} and Edgar Benjamin {Montufar Jimenez}",
  title="Biodegradable WE43 Mg alloy/hydroxyapatite interpenetrating phase composites with reduced hydrogen evolution",
  journal="Bioactive Materials",
  year="2024",
  volume="42",
  number="12",
  pages="519--530",
  doi="10.1016/j.bioactmat.2024.08.048",
  issn="2452-199X",
  url="https://www.sciencedirect.com/science/article/pii/S2452199X24003876"
}