A study of biological effects of immortalized oleaginous yeasts biomass on human health

abstrakt

angličtina

Red yeasts belong to non-conventional yeasts and exhibit many interesting properties. Yeast biomass contains valuable bioactive compounds—fatty acids, glucans, certain essential amino acids, many antioxidants, provitamins, and quinones. Four non-conventional oleaginous and pigmented yeast strains of Metschnikowia pulcherrima, Cystofilobasidium infirmominiatum, Phaffia rhodozyma, and Rhodotorula kratochvilovae were used in this study. Complex yeast extracts were prepared and tested for biological activity, safety, and effect on human health. Both antioxidant and antibacterial effects were confirmed in all yeast cell lysates. The safety of red yeast cell lysates was verified by the MTT test on human cell lines. No cytotoxicity in the mouse melanoma B16F1 cell line was found in concentrations up to 20% of rehydrated biomass in cell medium. All of the extracts were cytotoxic at a concentration of 5 mg of extract/g of dry biomass. All the pigmented yeast extracts showed some positive results for apoptosis of murine melanoma cell lines and are therefore strong candidates positively effect human health. Based on the results of the present study, it can be concluded that oleaginous pigmented yeast cells and cellular extracts have beneficial effects in the fight against bacteria and also have a strong antioxidant effect. Red yeast cell biomass is a prospective material with many attractive biological functions and can be used in the food industry, as a pharmaceutical material, or in the feed industry.

red yeasts, immortalized biomass, biological effects

MÁROVÁ, I.; BENDOVÁ, A.; SZOTKOWSKI, M.

16. 5. 2023

Chemický ústav SAV BRatislava, Slovensko

Bratislava, SR

1336-4839

Programme ABSTRACTS, 47th ACY Conference

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1336-4839

34th Annual Conference on Yeasts, Book of abstracts

47

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Slovenská republika

71

71

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