INTERACTION OF DRUGS WITH SOIL ORGANIC MATTER STUDIED BY MICROCALORIMETRY

článek ve sborníku ve WoS nebo Scopus

angličtina

he usage of pharmaceuticals increases worldwide every year. The residues of these substances are excreted by the human or animal bodies and thus come into direct contact with the environment, mainly soils and ground water. The accumulation of pharmaceuticals in natural ecosystems may be problematic in the future therefore the knowledge of their behaviour, transport and interactions in the ecosystems is essential for their treatment. The most reactive substances in soils are humic as well as fulvic substances. Two fulvic acids stand as the model reactants with different pharmaceuticals in this study. These reactive compounds contain several kinds of active functional groups, such as hydrophilic hydroxylic or carboxylic groups, and also diverse hydrophobic structures. The interactions between fulvic acids and solutions of pure drugs were studied by isothermal titration calorimetry. The aim of the study was to observe the heat effects of the interactions and to describe the intensity of the binding process.

drug; Humic substances; interaction; microcalorimetry

KROUSKÁ, J.; PAPKO, N.; KLUČÁKOVÁ, M.

19. 10. 2022

9788088365099

NANOCON Conference Proceedings - International Conference on Nanomaterials

255

259

5

https://www.scopus.com/record/display.uri?eid=2-s2.0-85151338657&origin=inward&txGid=5e734680b209dca37207e6bf854d0036